Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold

Brooke A. Rosenzweig, Nathan T. Ross, Debarati M. Tagore, Janarthanan Jayawickramarajah, Ishu Saraogi, Andrew Hamilton

Research output: Contribution to journalArticle

Abstract

A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and a "reporter" face has been generated. When phosphocholine is appended to the proteinbinding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.

Original languageEnglish (US)
Pages (from-to)5020-5021
Number of pages2
JournalJournal of the American Chemical Society
Volume131
Issue number14
DOIs
StatePublished - Apr 15 2009

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Phosphorylcholine
Protein Binding
Scaffolds
C-Reactive Protein
Heart Diseases
DNA
Inflammation
Molecules
Biomolecules
Proteins
isoguanosine

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Biochemistry
  • Colloid and Surface Chemistry
  • Medicine(all)

Cite this

Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold. / Rosenzweig, Brooke A.; Ross, Nathan T.; Tagore, Debarati M.; Jayawickramarajah, Janarthanan; Saraogi, Ishu; Hamilton, Andrew.

In: Journal of the American Chemical Society, Vol. 131, No. 14, 15.04.2009, p. 5020-5021.

Research output: Contribution to journalArticle

Rosenzweig, Brooke A. ; Ross, Nathan T. ; Tagore, Debarati M. ; Jayawickramarajah, Janarthanan ; Saraogi, Ishu ; Hamilton, Andrew. / Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold. In: Journal of the American Chemical Society. 2009 ; Vol. 131, No. 14. pp. 5020-5021.
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