Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918

Martha I. Nelson, Cécile Viboud, Lone Simonsen, Ryan T. Bennett, Sara B. Griesemer, Kirsten St. George, Jill Taylor, David J. Spiro, Naomi A. Sengamalay, Elodie Ghedin, Jeffery K. Taubenberger, Edward C. Holmes

Research output: Contribution to journalArticle

Abstract

The H1N1 subtype of influenza A virus has caused substantial morbidity and mortality in humans, first documented in the global pandemic of 1918 and continuing to the present day. Despite this disease burden, the evolutionary history of the A/H1N1 virus is not well understood, particularly whether there is a virological basis for several notable epidemics of unusual severity in the 1940s and 1950s. Using a data set of 71 representative complete genome sequences sampled between 1918 and 2006, we show that segmental reassortment has played an important role in the genomic evolution of A/H1N1 since 1918. Specifically, we demonstrate that an A/H1N1 isolate from the 1947 epidemic acquired novel PB2 and HA genes through intra-subtype reassortment, which may explain the abrupt antigenic evolution of this virus. Similarly, the 1951 influenza epidemic may also have been associated with reassortant A/H1N1 viruses. Intra-subtype reassortment therefore appears to be a more important process in the evolution and epidemiology of H1N1 influenza A virus than previously realized.

Original languageEnglish (US)
JournalPLoS Pathogens
Volume4
Issue number2
DOIs
StatePublished - Feb 2008

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H1N1 Subtype Influenza A Virus
Influenza A virus
History
Pandemics
Human Influenza
Epidemiology
Genome
Viruses
Morbidity
Mortality
Genes

ASJC Scopus subject areas

  • Microbiology
  • Parasitology
  • Virology
  • Immunology
  • Genetics
  • Molecular Biology

Cite this

Nelson, M. I., Viboud, C., Simonsen, L., Bennett, R. T., Griesemer, S. B., St. George, K., ... Holmes, E. C. (2008). Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. PLoS Pathogens, 4(2). https://doi.org/10.1371/journal.ppat.1000012

Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. / Nelson, Martha I.; Viboud, Cécile; Simonsen, Lone; Bennett, Ryan T.; Griesemer, Sara B.; St. George, Kirsten; Taylor, Jill; Spiro, David J.; Sengamalay, Naomi A.; Ghedin, Elodie; Taubenberger, Jeffery K.; Holmes, Edward C.

In: PLoS Pathogens, Vol. 4, No. 2, 02.2008.

Research output: Contribution to journalArticle

Nelson, MI, Viboud, C, Simonsen, L, Bennett, RT, Griesemer, SB, St. George, K, Taylor, J, Spiro, DJ, Sengamalay, NA, Ghedin, E, Taubenberger, JK & Holmes, EC 2008, 'Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918', PLoS Pathogens, vol. 4, no. 2. https://doi.org/10.1371/journal.ppat.1000012
Nelson, Martha I. ; Viboud, Cécile ; Simonsen, Lone ; Bennett, Ryan T. ; Griesemer, Sara B. ; St. George, Kirsten ; Taylor, Jill ; Spiro, David J. ; Sengamalay, Naomi A. ; Ghedin, Elodie ; Taubenberger, Jeffery K. ; Holmes, Edward C. / Multiple reassortment events in the evolutionary history of H1N1 influenza A virus since 1918. In: PLoS Pathogens. 2008 ; Vol. 4, No. 2.
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