Multiple overlapping processes underlying short-term synaptic enhancement

Stephen A. Fisher, Thomas M. Fischer, Thomas J. Carew

Research output: Contribution to journalArticle

Abstract

Recently there have been exciting advances in understanding the mechanisms and functional roles of a form of short-term synaptic enhancement (STE) that results from an activity-dependent accumulation of Ca2+ in the presynaptic terminal. This form of STE is composed of at least four processes: fast-decaying facilitation (F1), slow-decaying facilitation (F2), augmentation (AUG) and post-tetanic potentiation (PTP). Recent results suggest that these processes can now be distinguished mechanistically by the site of their induction within the presynaptic terminal: F1 and F2 appear to be induced by a rapid, high concentration of Ca2+ at or near the site of exocytosis, whereas AUC and PTP seem to be induced by lower levels of Ca2+ with slower kinetics, possibly within the core of the terminal. STE is highly conserved across diverse species, and appears to serve as a flexible mechanism for temporal information processing in systems ranging from peripheral motor control to higher cortical integration.

Original languageEnglish (US)
Pages (from-to)170-177
Number of pages8
JournalTrends in Neurosciences
Volume20
Issue number4
DOIs
StatePublished - Apr 1 1997

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Presynaptic Terminals
Exocytosis
Automatic Data Processing
Area Under Curve

ASJC Scopus subject areas

  • Neuroscience(all)

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Multiple overlapping processes underlying short-term synaptic enhancement. / Fisher, Stephen A.; Fischer, Thomas M.; Carew, Thomas J.

In: Trends in Neurosciences, Vol. 20, No. 4, 01.04.1997, p. 170-177.

Research output: Contribution to journalArticle

Fisher, Stephen A. ; Fischer, Thomas M. ; Carew, Thomas J. / Multiple overlapping processes underlying short-term synaptic enhancement. In: Trends in Neurosciences. 1997 ; Vol. 20, No. 4. pp. 170-177.
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