Multiple conductance levels in rat heart inner mitochondrial membranes studied by patch clamping

Dmitry B. Zorow, Kathleen W. Kinnally, Sean Perini, Henry Tedeschi

Research output: Contribution to journalArticle


The behavior of the mitochondrial inner membrane multiple conductance channel (MCC) which has a peak conductance of 1-1.5 nS has been examined in rat heart mitochondria, MCC can display several unique characteristics: (a) prolonged open and closed times on the order of seconds to minutes, (b) a voltage dependence in which MCC opens (negative potential) or closes (positive potential) generally in steps, (c) a response to inhibitors such as amiodarone in steps corresponding at least approximately to those in (b), (d) a 'free-running mode' in which the current level rapidly fluctuates between a minimum of nine conductance levels but with a preferred occupation of the 0.5-0.7 nS levels, and (e) very large transitions (1-1.5 nS) resolved at 4 kHz bandwidth as single events with variable mean open time.

Original languageEnglish (US)
Pages (from-to)263-270
Number of pages8
JournalBBA - Biomembranes
Issue number2
StatePublished - Apr 13 1992



  • (Rat heart)
  • Amiodarone
  • Ion channel
  • Mitochondrial channel
  • Mitochondrial membrane
  • Patch clamp
  • Permeability

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Cell Biology

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