Multiple component networks support working memory in prefrontal cortex

David A. Markowitz, Clayton Curtis, Bijan Pesaran

Research output: Contribution to journalArticle

Abstract

Lateral prefrontal cortex (PFC) is regarded as the hub of the brain's working memory (WM) system, but it remains unclear whether WM is supported by a single distributed network or multiple specialized network components in this region. To investigate this problem, we recorded from neurons in PFC while monkeys made delayed eye movements guided by memory or vision. We show that neuronal responses during these tasks map to three anatomically specific modes of persistent activity. The first two modes encode early and late forms of information storage, whereas the third mode encodes response preparation. Neurons that reflect these modes are concentrated at different anatomical locations in PFC and exhibit distinct patterns of coordinated firing rates and spike timing during WM, consistent with distinct networks. These findings support multiple component models of WM and consequently predict distinct failures that could contribute to neurologic dysfunction.

Original languageEnglish (US)
Pages (from-to)11084-11089
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume112
Issue number35
DOIs
StatePublished - Sep 1 2015

Fingerprint

Prefrontal Cortex
Short-Term Memory
Neurons
Information Storage and Retrieval
Eye Movements
Neurologic Manifestations
Haplorhini
Brain

Keywords

  • Coherence
  • Macaque
  • Prefrontal cortex
  • Working memory

ASJC Scopus subject areas

  • General

Cite this

Multiple component networks support working memory in prefrontal cortex. / Markowitz, David A.; Curtis, Clayton; Pesaran, Bijan.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, No. 35, 01.09.2015, p. 11084-11089.

Research output: Contribution to journalArticle

@article{333a7bea79ac4954b131a42165535384,
title = "Multiple component networks support working memory in prefrontal cortex",
abstract = "Lateral prefrontal cortex (PFC) is regarded as the hub of the brain's working memory (WM) system, but it remains unclear whether WM is supported by a single distributed network or multiple specialized network components in this region. To investigate this problem, we recorded from neurons in PFC while monkeys made delayed eye movements guided by memory or vision. We show that neuronal responses during these tasks map to three anatomically specific modes of persistent activity. The first two modes encode early and late forms of information storage, whereas the third mode encodes response preparation. Neurons that reflect these modes are concentrated at different anatomical locations in PFC and exhibit distinct patterns of coordinated firing rates and spike timing during WM, consistent with distinct networks. These findings support multiple component models of WM and consequently predict distinct failures that could contribute to neurologic dysfunction.",
keywords = "Coherence, Macaque, Prefrontal cortex, Working memory",
author = "Markowitz, {David A.} and Clayton Curtis and Bijan Pesaran",
year = "2015",
month = "9",
day = "1",
doi = "10.1073/pnas.1504172112",
language = "English (US)",
volume = "112",
pages = "11084--11089",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
number = "35",

}

TY - JOUR

T1 - Multiple component networks support working memory in prefrontal cortex

AU - Markowitz, David A.

AU - Curtis, Clayton

AU - Pesaran, Bijan

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Lateral prefrontal cortex (PFC) is regarded as the hub of the brain's working memory (WM) system, but it remains unclear whether WM is supported by a single distributed network or multiple specialized network components in this region. To investigate this problem, we recorded from neurons in PFC while monkeys made delayed eye movements guided by memory or vision. We show that neuronal responses during these tasks map to three anatomically specific modes of persistent activity. The first two modes encode early and late forms of information storage, whereas the third mode encodes response preparation. Neurons that reflect these modes are concentrated at different anatomical locations in PFC and exhibit distinct patterns of coordinated firing rates and spike timing during WM, consistent with distinct networks. These findings support multiple component models of WM and consequently predict distinct failures that could contribute to neurologic dysfunction.

AB - Lateral prefrontal cortex (PFC) is regarded as the hub of the brain's working memory (WM) system, but it remains unclear whether WM is supported by a single distributed network or multiple specialized network components in this region. To investigate this problem, we recorded from neurons in PFC while monkeys made delayed eye movements guided by memory or vision. We show that neuronal responses during these tasks map to three anatomically specific modes of persistent activity. The first two modes encode early and late forms of information storage, whereas the third mode encodes response preparation. Neurons that reflect these modes are concentrated at different anatomical locations in PFC and exhibit distinct patterns of coordinated firing rates and spike timing during WM, consistent with distinct networks. These findings support multiple component models of WM and consequently predict distinct failures that could contribute to neurologic dysfunction.

KW - Coherence

KW - Macaque

KW - Prefrontal cortex

KW - Working memory

UR - http://www.scopus.com/inward/record.url?scp=84941002438&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941002438&partnerID=8YFLogxK

U2 - 10.1073/pnas.1504172112

DO - 10.1073/pnas.1504172112

M3 - Article

C2 - 26283366

AN - SCOPUS:84941002438

VL - 112

SP - 11084

EP - 11089

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 35

ER -