Multifunctionalization of dendrimers through orthogonal transformations

Poorva Goyal, Kunsang Yoon, Marcus Weck

Research output: Contribution to journalArticle

Abstract

A straightforward methodology for the synthesis of multifunctionalized dendrimers that is based on an orthogonal functionalization strategy has been developed. Polyamide-based dendrimers that possess both a single aldehyde and a single azide moiety on their periphery have been synthesized by using a convergent synthetic strategy. These dendrimers can be functionalized quantitatively with small organic and biological molecules that contain hydrazide and/or alkyne groups in which each functional moiety is completely specific for its complementary motif. This orthogonal functionalization strategy has the potential to be used to synthesize multifunctional dendrimers for a variety of applications, which range from targeted biological delivery vehicles to optical materials.

Original languageEnglish (US)
Pages (from-to)8801-8810
Number of pages10
JournalChemistry - A European Journal
Volume13
Issue number31
DOIs
StatePublished - Nov 8 2007

Keywords

  • Chemical biology
  • Click chemistry
  • Dendrimers
  • Functionalization

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry

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