Multi-trait evolution in a cave fish, Astyanax mexicanus

Meredith Protas, Inna Tabansky, Melissa Conrad, Joshua B. Gross, Oriol Vidal, Clifford J. Tabin, Richard Borowsky

Research output: Contribution to journalArticle

Abstract

When surface species colonize caves, a characteristic suite of traits eventually evolves over time, regardless of species. The genetic basis of the inevitable appearance of these very similar phenotypes was investigated through quantitative trait loci (QTL) mapping of 12 traits that differ significantly between the recently evolved (<1 Myr). Mexican cave tetra and its surface conspecific. The traits were a representative set, including eye size, pigment cell numbers, chemical sensitivity, body and skull morphology, standard length, and metabolism. We used both single- and multi-trait models for QTL mapping. QTL effects of these traits were significantly clustered in the genome. We mapped 13 regions in the genome with QTL effects on from three to nine traits. These clusters could be multigenic or could represent single locus with pleiotropic alleles. Given the relatively short time available to construct clusters from unlinked genes through genomic rearrangement, and the counterintuitive polarities of some of the substitution effects, we argue that at least some of the clusters must have a pleiotropic basis.

Original languageEnglish (US)
Pages (from-to)196-209
Number of pages14
JournalEvolution and Development
Volume10
Issue number2
DOIs
StatePublished - Mar 2008

Fingerprint

Quantitative Trait Loci
caves
cave
quantitative trait loci
Fishes
fish
genome
Genome
skull
phenotype
pigment
genomics
allele
substitution
Multigene Family
metabolism
Skull
gene
Cell Count
eyes

ASJC Scopus subject areas

  • Genetics
  • Embryology
  • Developmental Biology
  • Ecology, Evolution, Behavior and Systematics
  • Agricultural and Biological Sciences (miscellaneous)
  • Genetics(clinical)
  • Agricultural and Biological Sciences(all)

Cite this

Protas, M., Tabansky, I., Conrad, M., Gross, J. B., Vidal, O., Tabin, C. J., & Borowsky, R. (2008). Multi-trait evolution in a cave fish, Astyanax mexicanus. Evolution and Development, 10(2), 196-209. https://doi.org/10.1111/j.1525-142X.2008.00227.x

Multi-trait evolution in a cave fish, Astyanax mexicanus. / Protas, Meredith; Tabansky, Inna; Conrad, Melissa; Gross, Joshua B.; Vidal, Oriol; Tabin, Clifford J.; Borowsky, Richard.

In: Evolution and Development, Vol. 10, No. 2, 03.2008, p. 196-209.

Research output: Contribution to journalArticle

Protas, M, Tabansky, I, Conrad, M, Gross, JB, Vidal, O, Tabin, CJ & Borowsky, R 2008, 'Multi-trait evolution in a cave fish, Astyanax mexicanus', Evolution and Development, vol. 10, no. 2, pp. 196-209. https://doi.org/10.1111/j.1525-142X.2008.00227.x
Protas M, Tabansky I, Conrad M, Gross JB, Vidal O, Tabin CJ et al. Multi-trait evolution in a cave fish, Astyanax mexicanus. Evolution and Development. 2008 Mar;10(2):196-209. https://doi.org/10.1111/j.1525-142X.2008.00227.x
Protas, Meredith ; Tabansky, Inna ; Conrad, Melissa ; Gross, Joshua B. ; Vidal, Oriol ; Tabin, Clifford J. ; Borowsky, Richard. / Multi-trait evolution in a cave fish, Astyanax mexicanus. In: Evolution and Development. 2008 ; Vol. 10, No. 2. pp. 196-209.
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