Motion of molecular motor ratcheted by internal fluctuations and protein friction

A. Mogilner, M. Mangel, R. J. Baskin

Research output: Contribution to journalArticle

Abstract

We investigate theoretically a novel mechanism of transducing chemical energy into a directed force. A hypothetical motor protein is considered such that conformational changes induced by nucleotide binding and/or hydrolysis lead to asymmetric internal velocity fluctuations. We demonstrate that these fluctuations result in unidirectional motion if rectified by protein friction. The motor protein force-velocity relationship and other characteristics are computed based on analogy with known molecular motors.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalPhysics Letters A
Volume237
Issue number4-5
StatePublished - Jan 12 1998

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friction
proteins
chemical energy
nucleotides
hydrolysis

Keywords

  • Brownian ratchet
  • Molecular motors
  • Protein friction

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Motion of molecular motor ratcheted by internal fluctuations and protein friction. / Mogilner, A.; Mangel, M.; Baskin, R. J.

In: Physics Letters A, Vol. 237, No. 4-5, 12.01.1998, p. 297-306.

Research output: Contribution to journalArticle

Mogilner, A. ; Mangel, M. ; Baskin, R. J. / Motion of molecular motor ratcheted by internal fluctuations and protein friction. In: Physics Letters A. 1998 ; Vol. 237, No. 4-5. pp. 297-306.
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