Mortality and causes of death after first ischemic stroke: The Northern Manhattan stroke study

Andreas Hartmann, T. Rundek, H. Mast, M. C. Paik, B. Boden-Albala, J. P. Mohr, R. L. Sacco

Research output: Contribution to journalArticle

Abstract

Objective: To analyze the early and long-term causes of death after first ischemic stroke in the multiethnic northern Manhattan community. Methods: In the prospective, population-based Northern Manhattan Stroke Study, 980 patients with first ischemic stroke (mean age 70 years; 56% women; 49% Caribbean Hispanic, 31% black, 20% white) were followed for a mean of 3 years. Causes of death were classified as vascular (incident stroke, recurrent stroke, cardiac) or nonvascular. Life table analyses were used to assess mortality risks among different race-ethnic groups. Early (≤1 month) vs long-term (>1 month to 5 years) causes of death were compared. Results: Among the 980 patients followed, 278 (28%) died; 47 (5%) died during the first month. Cumulative mortality risk was 5% at 1 month, 16% after 1 year, 29% after 3 years, and 41% after 5 years. The proportion of vascular deaths among all deaths was 75% at 1 month and 43% thereafter (p = 0.001). Stroke, either incident (53%) or recurrent (4%), caused early deaths in 57% and long-term deaths in 14% (p = 0.001). Overall mortality risks did not differ significantly among race-ethnic groups. However, the proportion of incident stroke-related early deaths was 85% in Caribbean Hispanic patients, 33% in white patients, and 25% in black patients (p = 0.002). Conclusions: Among patients with first ischemic stroke, incident stroke is the leading cause of early deaths. A large proportion of long-term deaths are nonvascular in origin. Despite similar overall mortality rates in race-ethnic groups, our data suggest a higher incident stroke-related early mortality among Caribbean Hispanics.

Original languageEnglish (US)
Pages (from-to)2000-2005
Number of pages6
JournalNeurology
Volume57
Issue number11
StatePublished - Dec 11 2001

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Cause of Death
Stroke
Mortality
Hispanic Americans
Ethnic Groups
Blood Vessels
Life Tables
Population

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Hartmann, A., Rundek, T., Mast, H., Paik, M. C., Boden-Albala, B., Mohr, J. P., & Sacco, R. L. (2001). Mortality and causes of death after first ischemic stroke: The Northern Manhattan stroke study. Neurology, 57(11), 2000-2005.

Mortality and causes of death after first ischemic stroke : The Northern Manhattan stroke study. / Hartmann, Andreas; Rundek, T.; Mast, H.; Paik, M. C.; Boden-Albala, B.; Mohr, J. P.; Sacco, R. L.

In: Neurology, Vol. 57, No. 11, 11.12.2001, p. 2000-2005.

Research output: Contribution to journalArticle

Hartmann, A, Rundek, T, Mast, H, Paik, MC, Boden-Albala, B, Mohr, JP & Sacco, RL 2001, 'Mortality and causes of death after first ischemic stroke: The Northern Manhattan stroke study', Neurology, vol. 57, no. 11, pp. 2000-2005.
Hartmann A, Rundek T, Mast H, Paik MC, Boden-Albala B, Mohr JP et al. Mortality and causes of death after first ischemic stroke: The Northern Manhattan stroke study. Neurology. 2001 Dec 11;57(11):2000-2005.
Hartmann, Andreas ; Rundek, T. ; Mast, H. ; Paik, M. C. ; Boden-Albala, B. ; Mohr, J. P. ; Sacco, R. L. / Mortality and causes of death after first ischemic stroke : The Northern Manhattan stroke study. In: Neurology. 2001 ; Vol. 57, No. 11. pp. 2000-2005.
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abstract = "Objective: To analyze the early and long-term causes of death after first ischemic stroke in the multiethnic northern Manhattan community. Methods: In the prospective, population-based Northern Manhattan Stroke Study, 980 patients with first ischemic stroke (mean age 70 years; 56{\%} women; 49{\%} Caribbean Hispanic, 31{\%} black, 20{\%} white) were followed for a mean of 3 years. Causes of death were classified as vascular (incident stroke, recurrent stroke, cardiac) or nonvascular. Life table analyses were used to assess mortality risks among different race-ethnic groups. Early (≤1 month) vs long-term (>1 month to 5 years) causes of death were compared. Results: Among the 980 patients followed, 278 (28{\%}) died; 47 (5{\%}) died during the first month. Cumulative mortality risk was 5{\%} at 1 month, 16{\%} after 1 year, 29{\%} after 3 years, and 41{\%} after 5 years. The proportion of vascular deaths among all deaths was 75{\%} at 1 month and 43{\%} thereafter (p = 0.001). Stroke, either incident (53{\%}) or recurrent (4{\%}), caused early deaths in 57{\%} and long-term deaths in 14{\%} (p = 0.001). Overall mortality risks did not differ significantly among race-ethnic groups. However, the proportion of incident stroke-related early deaths was 85{\%} in Caribbean Hispanic patients, 33{\%} in white patients, and 25{\%} in black patients (p = 0.002). Conclusions: Among patients with first ischemic stroke, incident stroke is the leading cause of early deaths. A large proportion of long-term deaths are nonvascular in origin. Despite similar overall mortality rates in race-ethnic groups, our data suggest a higher incident stroke-related early mortality among Caribbean Hispanics.",
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AU - Rundek, T.

AU - Mast, H.

AU - Paik, M. C.

AU - Boden-Albala, B.

AU - Mohr, J. P.

AU - Sacco, R. L.

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N2 - Objective: To analyze the early and long-term causes of death after first ischemic stroke in the multiethnic northern Manhattan community. Methods: In the prospective, population-based Northern Manhattan Stroke Study, 980 patients with first ischemic stroke (mean age 70 years; 56% women; 49% Caribbean Hispanic, 31% black, 20% white) were followed for a mean of 3 years. Causes of death were classified as vascular (incident stroke, recurrent stroke, cardiac) or nonvascular. Life table analyses were used to assess mortality risks among different race-ethnic groups. Early (≤1 month) vs long-term (>1 month to 5 years) causes of death were compared. Results: Among the 980 patients followed, 278 (28%) died; 47 (5%) died during the first month. Cumulative mortality risk was 5% at 1 month, 16% after 1 year, 29% after 3 years, and 41% after 5 years. The proportion of vascular deaths among all deaths was 75% at 1 month and 43% thereafter (p = 0.001). Stroke, either incident (53%) or recurrent (4%), caused early deaths in 57% and long-term deaths in 14% (p = 0.001). Overall mortality risks did not differ significantly among race-ethnic groups. However, the proportion of incident stroke-related early deaths was 85% in Caribbean Hispanic patients, 33% in white patients, and 25% in black patients (p = 0.002). Conclusions: Among patients with first ischemic stroke, incident stroke is the leading cause of early deaths. A large proportion of long-term deaths are nonvascular in origin. Despite similar overall mortality rates in race-ethnic groups, our data suggest a higher incident stroke-related early mortality among Caribbean Hispanics.

AB - Objective: To analyze the early and long-term causes of death after first ischemic stroke in the multiethnic northern Manhattan community. Methods: In the prospective, population-based Northern Manhattan Stroke Study, 980 patients with first ischemic stroke (mean age 70 years; 56% women; 49% Caribbean Hispanic, 31% black, 20% white) were followed for a mean of 3 years. Causes of death were classified as vascular (incident stroke, recurrent stroke, cardiac) or nonvascular. Life table analyses were used to assess mortality risks among different race-ethnic groups. Early (≤1 month) vs long-term (>1 month to 5 years) causes of death were compared. Results: Among the 980 patients followed, 278 (28%) died; 47 (5%) died during the first month. Cumulative mortality risk was 5% at 1 month, 16% after 1 year, 29% after 3 years, and 41% after 5 years. The proportion of vascular deaths among all deaths was 75% at 1 month and 43% thereafter (p = 0.001). Stroke, either incident (53%) or recurrent (4%), caused early deaths in 57% and long-term deaths in 14% (p = 0.001). Overall mortality risks did not differ significantly among race-ethnic groups. However, the proportion of incident stroke-related early deaths was 85% in Caribbean Hispanic patients, 33% in white patients, and 25% in black patients (p = 0.002). Conclusions: Among patients with first ischemic stroke, incident stroke is the leading cause of early deaths. A large proportion of long-term deaths are nonvascular in origin. Despite similar overall mortality rates in race-ethnic groups, our data suggest a higher incident stroke-related early mortality among Caribbean Hispanics.

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