Morphometry of anatomical shape complexes with dense deformations and sparse parameters

Stanley Durrleman, Marcel Prastawa, Nicolas Charon, Julie R. Korenberg, Sarang Joshi, Guido Gerig, Alain Trouvé

    Research output: Contribution to journalArticle

    Abstract

    We propose a generic method for the statistical analysis of collections of anatomical shape complexes, namely sets of surfaces that were previously segmented and labeled in a group of subjects. The method estimates an anatomical model, the template complex, that is representative of the population under study. Its shape reflects anatomical invariants within the dataset. In addition, the method automatically places control points near the most variable parts of the template complex. Vectors attached to these points are parameters of deformations of the ambient 3D space. These deformations warp the template to each subject's complex in a way that preserves the organization of the anatomical structures. Multivariate statistical analysis is applied to these deformation parameters to test for group differences. Results of the statistical analysis are then expressed in terms of deformation patterns of the template complex, and can be visualized and interpreted. The user needs only to specify the topology of the template complex and the number of control points. The method then automatically estimates the shape of the template complex, the optimal position of control points and deformation parameters. The proposed approach is completely generic with respect to any type of application and well adapted to efficient use in clinical studies, in that it does not require point correspondence across surfaces and is robust to mesh imperfections such as holes, spikes, inconsistent orientation or irregular meshing.The approach is illustrated with a neuroimaging study of Down syndrome (DS). The results demonstrate that the complex of deep brain structures shows a statistically significant shape difference between control and DS subjects. The deformation-based modelingis able to classify subjects with very high specificity and sensitivity, thus showing important generalization capability even given a low sample size. We show that the results remain significant even if the number of control points, and hence the dimension of variables in the statistical model, are drastically reduced. The analysis may even suggest that parsimonious models have an increased statistical performance.The method has been implemented in the software Deformetrica, which is publicly available at www.deformetrica.org.

    Original languageEnglish (US)
    Pages (from-to)35-49
    Number of pages15
    JournalNeuroImage
    Volume101
    DOIs
    StatePublished - Nov 1 2014

    Fingerprint

    Down Syndrome
    Anatomic Models
    Statistical Models
    Neuroimaging
    Sample Size
    Software
    Multivariate Analysis
    Sensitivity and Specificity
    Brain
    Population
    Datasets
    Clinical Studies

    Keywords

    • Anatomy
    • Deformation
    • Morphometry
    • Shape
    • Statistics
    • Varifold

    ASJC Scopus subject areas

    • Cognitive Neuroscience
    • Neurology

    Cite this

    Durrleman, S., Prastawa, M., Charon, N., Korenberg, J. R., Joshi, S., Gerig, G., & Trouvé, A. (2014). Morphometry of anatomical shape complexes with dense deformations and sparse parameters. NeuroImage, 101, 35-49. https://doi.org/10.1016/j.neuroimage.2014.06.043

    Morphometry of anatomical shape complexes with dense deformations and sparse parameters. / Durrleman, Stanley; Prastawa, Marcel; Charon, Nicolas; Korenberg, Julie R.; Joshi, Sarang; Gerig, Guido; Trouvé, Alain.

    In: NeuroImage, Vol. 101, 01.11.2014, p. 35-49.

    Research output: Contribution to journalArticle

    Durrleman, S, Prastawa, M, Charon, N, Korenberg, JR, Joshi, S, Gerig, G & Trouvé, A 2014, 'Morphometry of anatomical shape complexes with dense deformations and sparse parameters', NeuroImage, vol. 101, pp. 35-49. https://doi.org/10.1016/j.neuroimage.2014.06.043
    Durrleman S, Prastawa M, Charon N, Korenberg JR, Joshi S, Gerig G et al. Morphometry of anatomical shape complexes with dense deformations and sparse parameters. NeuroImage. 2014 Nov 1;101:35-49. https://doi.org/10.1016/j.neuroimage.2014.06.043
    Durrleman, Stanley ; Prastawa, Marcel ; Charon, Nicolas ; Korenberg, Julie R. ; Joshi, Sarang ; Gerig, Guido ; Trouvé, Alain. / Morphometry of anatomical shape complexes with dense deformations and sparse parameters. In: NeuroImage. 2014 ; Vol. 101. pp. 35-49.
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