Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors

Martin Styner, Jeffrey A. Lieberman, Robert K. McClure, Daniel R. Weinberger, Douglas W. Jones, Guido Gerig

    Research output: Contribution to journalArticle

    Abstract

    The structural variability of lateral ventricles is poorly understood notwithstanding that enlarged size has been identified as an unspecific marker for psychiatric illness, including schizophrenia. This paper explores the effects of heritability and genetic risk for schizophrenia reflected in ventricular size and structure. We examined ventricular size and shape in the MRI studies of monozygotic (MZ) twin pairs discordant for schizophrenia (DS), healthy MZ twin pairs, healthy dizygotic twin pairs, and healthy nonrelated subject pairs. Heritability and effect due to disease were analyzed in two tests. First, heritability was examined by ventricle similarity between pairs of co-twins. Results show that co-twin ventricle shape similarity decreases with decreasing genetic identity, an effect not seen in the volume analysis. Co-twin shape similarity of healthy MZ twins did not differ from DS MZ twins. Second, the disease effect was examined through the ventricular differences of DS subjects to a template shape representing healthy subjects. Affected DS twins showed shape differences from healthy subjects on the left and right sides. Interestingly, unaffected DS twins also showed significant shape differences from healthy subjects for both sides. Volume comparisons did not show differences between these groups. Locality of shape difference suggests that the ventricular shape of the anterior and posterior regions is under genetic influence in both healthy controls and schizophrenia patients. Affected and unaffected groups demonstrate main shape differences, compared with healthy controls, only in the posterior region. Our results suggest that genetics have a stronger influence on the shape of lateral ventricles than do the disease-related changes in schizophrenia.

    Original languageEnglish (US)
    Pages (from-to)4872-4877
    Number of pages6
    JournalProceedings of the National Academy of Sciences of the United States of America
    Volume102
    Issue number13
    DOIs
    StatePublished - Mar 29 2005

    Fingerprint

    Inborn Genetic Diseases
    Lateral Ventricles
    Schizophrenia
    Monozygotic Twins
    Healthy Volunteers
    Dizygotic Twins
    Pedigree
    Psychiatry

    Keywords

    • Brain morphometry
    • MRI
    • Shape analysis
    • Twin study

    ASJC Scopus subject areas

    • Genetics
    • General

    Cite this

    Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. / Styner, Martin; Lieberman, Jeffrey A.; McClure, Robert K.; Weinberger, Daniel R.; Jones, Douglas W.; Gerig, Guido.

    In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, No. 13, 29.03.2005, p. 4872-4877.

    Research output: Contribution to journalArticle

    Styner, Martin ; Lieberman, Jeffrey A. ; McClure, Robert K. ; Weinberger, Daniel R. ; Jones, Douglas W. ; Gerig, Guido. / Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors. In: Proceedings of the National Academy of Sciences of the United States of America. 2005 ; Vol. 102, No. 13. pp. 4872-4877.
    @article{e108bef68d3b4b9fb0fde6b23d0a5a57,
    title = "Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors",
    abstract = "The structural variability of lateral ventricles is poorly understood notwithstanding that enlarged size has been identified as an unspecific marker for psychiatric illness, including schizophrenia. This paper explores the effects of heritability and genetic risk for schizophrenia reflected in ventricular size and structure. We examined ventricular size and shape in the MRI studies of monozygotic (MZ) twin pairs discordant for schizophrenia (DS), healthy MZ twin pairs, healthy dizygotic twin pairs, and healthy nonrelated subject pairs. Heritability and effect due to disease were analyzed in two tests. First, heritability was examined by ventricle similarity between pairs of co-twins. Results show that co-twin ventricle shape similarity decreases with decreasing genetic identity, an effect not seen in the volume analysis. Co-twin shape similarity of healthy MZ twins did not differ from DS MZ twins. Second, the disease effect was examined through the ventricular differences of DS subjects to a template shape representing healthy subjects. Affected DS twins showed shape differences from healthy subjects on the left and right sides. Interestingly, unaffected DS twins also showed significant shape differences from healthy subjects for both sides. Volume comparisons did not show differences between these groups. Locality of shape difference suggests that the ventricular shape of the anterior and posterior regions is under genetic influence in both healthy controls and schizophrenia patients. Affected and unaffected groups demonstrate main shape differences, compared with healthy controls, only in the posterior region. Our results suggest that genetics have a stronger influence on the shape of lateral ventricles than do the disease-related changes in schizophrenia.",
    keywords = "Brain morphometry, MRI, Shape analysis, Twin study",
    author = "Martin Styner and Lieberman, {Jeffrey A.} and McClure, {Robert K.} and Weinberger, {Daniel R.} and Jones, {Douglas W.} and Guido Gerig",
    year = "2005",
    month = "3",
    day = "29",
    doi = "10.1073/pnas.0501117102",
    language = "English (US)",
    volume = "102",
    pages = "4872--4877",
    journal = "Proceedings of the National Academy of Sciences of the United States of America",
    issn = "0027-8424",
    number = "13",

    }

    TY - JOUR

    T1 - Morphometric analysis of lateral ventricles in schizophrenia and healthy controls regarding genetic and disease-specific factors

    AU - Styner, Martin

    AU - Lieberman, Jeffrey A.

    AU - McClure, Robert K.

    AU - Weinberger, Daniel R.

    AU - Jones, Douglas W.

    AU - Gerig, Guido

    PY - 2005/3/29

    Y1 - 2005/3/29

    N2 - The structural variability of lateral ventricles is poorly understood notwithstanding that enlarged size has been identified as an unspecific marker for psychiatric illness, including schizophrenia. This paper explores the effects of heritability and genetic risk for schizophrenia reflected in ventricular size and structure. We examined ventricular size and shape in the MRI studies of monozygotic (MZ) twin pairs discordant for schizophrenia (DS), healthy MZ twin pairs, healthy dizygotic twin pairs, and healthy nonrelated subject pairs. Heritability and effect due to disease were analyzed in two tests. First, heritability was examined by ventricle similarity between pairs of co-twins. Results show that co-twin ventricle shape similarity decreases with decreasing genetic identity, an effect not seen in the volume analysis. Co-twin shape similarity of healthy MZ twins did not differ from DS MZ twins. Second, the disease effect was examined through the ventricular differences of DS subjects to a template shape representing healthy subjects. Affected DS twins showed shape differences from healthy subjects on the left and right sides. Interestingly, unaffected DS twins also showed significant shape differences from healthy subjects for both sides. Volume comparisons did not show differences between these groups. Locality of shape difference suggests that the ventricular shape of the anterior and posterior regions is under genetic influence in both healthy controls and schizophrenia patients. Affected and unaffected groups demonstrate main shape differences, compared with healthy controls, only in the posterior region. Our results suggest that genetics have a stronger influence on the shape of lateral ventricles than do the disease-related changes in schizophrenia.

    AB - The structural variability of lateral ventricles is poorly understood notwithstanding that enlarged size has been identified as an unspecific marker for psychiatric illness, including schizophrenia. This paper explores the effects of heritability and genetic risk for schizophrenia reflected in ventricular size and structure. We examined ventricular size and shape in the MRI studies of monozygotic (MZ) twin pairs discordant for schizophrenia (DS), healthy MZ twin pairs, healthy dizygotic twin pairs, and healthy nonrelated subject pairs. Heritability and effect due to disease were analyzed in two tests. First, heritability was examined by ventricle similarity between pairs of co-twins. Results show that co-twin ventricle shape similarity decreases with decreasing genetic identity, an effect not seen in the volume analysis. Co-twin shape similarity of healthy MZ twins did not differ from DS MZ twins. Second, the disease effect was examined through the ventricular differences of DS subjects to a template shape representing healthy subjects. Affected DS twins showed shape differences from healthy subjects on the left and right sides. Interestingly, unaffected DS twins also showed significant shape differences from healthy subjects for both sides. Volume comparisons did not show differences between these groups. Locality of shape difference suggests that the ventricular shape of the anterior and posterior regions is under genetic influence in both healthy controls and schizophrenia patients. Affected and unaffected groups demonstrate main shape differences, compared with healthy controls, only in the posterior region. Our results suggest that genetics have a stronger influence on the shape of lateral ventricles than do the disease-related changes in schizophrenia.

    KW - Brain morphometry

    KW - MRI

    KW - Shape analysis

    KW - Twin study

    UR - http://www.scopus.com/inward/record.url?scp=16344391965&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=16344391965&partnerID=8YFLogxK

    U2 - 10.1073/pnas.0501117102

    DO - 10.1073/pnas.0501117102

    M3 - Article

    VL - 102

    SP - 4872

    EP - 4877

    JO - Proceedings of the National Academy of Sciences of the United States of America

    JF - Proceedings of the National Academy of Sciences of the United States of America

    SN - 0027-8424

    IS - 13

    ER -