Morning Fatigue Severity Profiles in Oncology Outpatients Receiving Chemotherapy

Fay Wright, Laura B. Dunn, Steven M. Paul, Yvette P. Conley, Jon D. Levine, Marilyn Hammer, Bruce A. Cooper, Christine Miaskowski, Kord M. Kober

Research output: Contribution to journalArticle

Abstract

Background Morning fatigue is a distinct symptom experienced during chemotherapy that demonstrates significant interindividual variability. Objectives The aims of this study were to identify subgroups with distinct morning fatigue profiles and evaluate how these subgroups differed by demographic, clinical, and symptom characteristics. Methods Outpatients (N = 1332) with breast, gastrointestinal, gynecological, or lung cancer completed questionnaires 6 times over 2 cycles of chemotherapy. Morning fatigue was assessed with the Lee Fatigue Scale. Latent profile analysis was used to identify distinct morning fatigue profiles. Results Four morning fatigue profiles (ie, very low, low, high, and very high) were identified. In the high and very high classes, all 6 morning fatigue scores were higher than the clinical cutoff score. Compared with those in the very low and low classes, patients in the very high class were younger and not married/partnered; lived alone; had higher incomes, higher comorbidity, and higher body mass index; and did not exercise regularly. Across the 4 classes, functional status and attentional function scores decreased and anxiety, depression, sleep disturbance, morning fatigue, and evening fatigue scores increased across the 2 cycles. Conclusion Results provide insights into modifiable risk factors for morning fatigue. These risk factors can be used to develop more targeted interventions. Implications for Practice Patients in the high and very high morning fatigue classes experienced high symptom and comorbidity burdens and significant decrements in functional status. Using this information, clinicians can identify patients who are at an increased risk for higher levels of morning fatigue and prescribe interventions to improve this devastating symptom.

Original languageEnglish (US)
Pages (from-to)355-364
Number of pages10
JournalCancer Nursing
Volume42
Issue number5
DOIs
StatePublished - Sep 1 2019

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Fatigue
Outpatients
Drug Therapy
Comorbidity
Gastrointestinal Neoplasms
Lung Neoplasms
Sleep
Breast
Body Mass Index
Anxiety
Demography
Exercise
Depression

Keywords

  • Chemotherapy
  • Diurnal variations
  • Latent class analysis
  • Morning fatigue
  • Symptom profiles

ASJC Scopus subject areas

  • Oncology
  • Oncology(nursing)

Cite this

Morning Fatigue Severity Profiles in Oncology Outpatients Receiving Chemotherapy. / Wright, Fay; Dunn, Laura B.; Paul, Steven M.; Conley, Yvette P.; Levine, Jon D.; Hammer, Marilyn; Cooper, Bruce A.; Miaskowski, Christine; Kober, Kord M.

In: Cancer Nursing, Vol. 42, No. 5, 01.09.2019, p. 355-364.

Research output: Contribution to journalArticle

Wright, F, Dunn, LB, Paul, SM, Conley, YP, Levine, JD, Hammer, M, Cooper, BA, Miaskowski, C & Kober, KM 2019, 'Morning Fatigue Severity Profiles in Oncology Outpatients Receiving Chemotherapy', Cancer Nursing, vol. 42, no. 5, pp. 355-364. https://doi.org/10.1097/NCC.0000000000000626
Wright, Fay ; Dunn, Laura B. ; Paul, Steven M. ; Conley, Yvette P. ; Levine, Jon D. ; Hammer, Marilyn ; Cooper, Bruce A. ; Miaskowski, Christine ; Kober, Kord M. / Morning Fatigue Severity Profiles in Oncology Outpatients Receiving Chemotherapy. In: Cancer Nursing. 2019 ; Vol. 42, No. 5. pp. 355-364.
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