Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid

Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil

Research output: Contribution to journalReview article

Abstract

Background Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60% of the clinically approved anticancer agents are either directly isolated from natural sources or are modified from natural lead molecules. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid has gained increasing attention in recent years as a potential anticancer agent. Purpose There is a large untapped source of phytochemical-based anticancer agents remaining to be explored. This review article aims to recapitulate different anticancer properties of SNG, and describes some of the molecular targets involved in exerting its effect. It also depicts the pharmacokinetic and toxicological properties of SNG, two parameters important in determining the druggability of a molecule. Methods Numerous in vivo and in vitro published studies have signified the anticancer properties of SNG. In order to collate and decipher these properties, an extensive literature search was conducted in PubMed, ScienceDirect, and Scopus using keywords followed by the evaluation of the relevant articles where the relevant reports are integrated and analyzed. Results Apart from inducing cell death, SNG inhibits pro-tumorigenic processes such as invasion, angiogenesis, and metastasis in different cancers. Moreover, SNG has been shown to synergistically enhance the sensitivity of several chemotherapeutic agents and is effective against a variety of multi-drug resistant cancers.

Original languageEnglish (US)
Pages (from-to)143-153
Number of pages11
JournalPhytomedicine
Volume34
DOIs
StatePublished - Oct 15 2017

Fingerprint

Benzophenanthridines
Alkaloids
Antineoplastic Agents
Neoplasms
Phytochemicals
PubMed
Toxicology
sanguinarine
Cell Death
Pharmacokinetics
Neoplasm Metastasis

Keywords

  • Anticancer
  • Apoptosis
  • Cell death
  • Phytochemicals
  • ROS
  • Sanguinarine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid. / Galadari, Sehamuddin; Rahman, Anees; Pallichankandy, Siraj; Thayyullathil, Faisal.

In: Phytomedicine, Vol. 34, 15.10.2017, p. 143-153.

Research output: Contribution to journalReview article

Galadari, Sehamuddin ; Rahman, Anees ; Pallichankandy, Siraj ; Thayyullathil, Faisal. / Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid. In: Phytomedicine. 2017 ; Vol. 34. pp. 143-153.
@article{d3be1468d4534555879663cecdb2279b,
title = "Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid",
abstract = "Background Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60{\%} of the clinically approved anticancer agents are either directly isolated from natural sources or are modified from natural lead molecules. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid has gained increasing attention in recent years as a potential anticancer agent. Purpose There is a large untapped source of phytochemical-based anticancer agents remaining to be explored. This review article aims to recapitulate different anticancer properties of SNG, and describes some of the molecular targets involved in exerting its effect. It also depicts the pharmacokinetic and toxicological properties of SNG, two parameters important in determining the druggability of a molecule. Methods Numerous in vivo and in vitro published studies have signified the anticancer properties of SNG. In order to collate and decipher these properties, an extensive literature search was conducted in PubMed, ScienceDirect, and Scopus using keywords followed by the evaluation of the relevant articles where the relevant reports are integrated and analyzed. Results Apart from inducing cell death, SNG inhibits pro-tumorigenic processes such as invasion, angiogenesis, and metastasis in different cancers. Moreover, SNG has been shown to synergistically enhance the sensitivity of several chemotherapeutic agents and is effective against a variety of multi-drug resistant cancers.",
keywords = "Anticancer, Apoptosis, Cell death, Phytochemicals, ROS, Sanguinarine",
author = "Sehamuddin Galadari and Anees Rahman and Siraj Pallichankandy and Faisal Thayyullathil",
year = "2017",
month = "10",
day = "15",
doi = "10.1016/j.phymed.2017.08.006",
language = "English (US)",
volume = "34",
pages = "143--153",
journal = "Phytomedicine",
issn = "0944-7113",
publisher = "Urban und Fischer Verlag Jena",

}

TY - JOUR

T1 - Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid

AU - Galadari, Sehamuddin

AU - Rahman, Anees

AU - Pallichankandy, Siraj

AU - Thayyullathil, Faisal

PY - 2017/10/15

Y1 - 2017/10/15

N2 - Background Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60% of the clinically approved anticancer agents are either directly isolated from natural sources or are modified from natural lead molecules. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid has gained increasing attention in recent years as a potential anticancer agent. Purpose There is a large untapped source of phytochemical-based anticancer agents remaining to be explored. This review article aims to recapitulate different anticancer properties of SNG, and describes some of the molecular targets involved in exerting its effect. It also depicts the pharmacokinetic and toxicological properties of SNG, two parameters important in determining the druggability of a molecule. Methods Numerous in vivo and in vitro published studies have signified the anticancer properties of SNG. In order to collate and decipher these properties, an extensive literature search was conducted in PubMed, ScienceDirect, and Scopus using keywords followed by the evaluation of the relevant articles where the relevant reports are integrated and analyzed. Results Apart from inducing cell death, SNG inhibits pro-tumorigenic processes such as invasion, angiogenesis, and metastasis in different cancers. Moreover, SNG has been shown to synergistically enhance the sensitivity of several chemotherapeutic agents and is effective against a variety of multi-drug resistant cancers.

AB - Background Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60% of the clinically approved anticancer agents are either directly isolated from natural sources or are modified from natural lead molecules. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid has gained increasing attention in recent years as a potential anticancer agent. Purpose There is a large untapped source of phytochemical-based anticancer agents remaining to be explored. This review article aims to recapitulate different anticancer properties of SNG, and describes some of the molecular targets involved in exerting its effect. It also depicts the pharmacokinetic and toxicological properties of SNG, two parameters important in determining the druggability of a molecule. Methods Numerous in vivo and in vitro published studies have signified the anticancer properties of SNG. In order to collate and decipher these properties, an extensive literature search was conducted in PubMed, ScienceDirect, and Scopus using keywords followed by the evaluation of the relevant articles where the relevant reports are integrated and analyzed. Results Apart from inducing cell death, SNG inhibits pro-tumorigenic processes such as invasion, angiogenesis, and metastasis in different cancers. Moreover, SNG has been shown to synergistically enhance the sensitivity of several chemotherapeutic agents and is effective against a variety of multi-drug resistant cancers.

KW - Anticancer

KW - Apoptosis

KW - Cell death

KW - Phytochemicals

KW - ROS

KW - Sanguinarine

UR - http://www.scopus.com/inward/record.url?scp=85028539259&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85028539259&partnerID=8YFLogxK

U2 - 10.1016/j.phymed.2017.08.006

DO - 10.1016/j.phymed.2017.08.006

M3 - Review article

VL - 34

SP - 143

EP - 153

JO - Phytomedicine

JF - Phytomedicine

SN - 0944-7113

ER -