Molecular recognition and catalysis: Incorporation of an "oxyanion hole" into a synthetic receptor

Erkang Fan, Cristina Vicent, Andrew D. Hamilton

Research output: Contribution to journalArticle


Acceleration of the 1,4-addition of a thiol to a maleimide can be achieved by binding the electrophile into a synthetic receptor containing hydrogen bonding sites that can interact with the carbonyl group and so stabilize the developing oxyanion in the transition state.

Original languageEnglish (US)
Pages (from-to)81-85
Number of pages5
JournalNew Journal of Chemistry
Issue number1
StatePublished - Jan 1 1997


ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Materials Chemistry

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