Molecular recognition and catalysis; acceleration of acyl transfer reactions by a hydrogen-bonding receptor

Paolo Tecilla, Andrew D. Hamilton

Research output: Contribution to journalArticle

Abstract

A hydrogen-bonding receptor containing an appended thiol has been synthesized and shown to cause large rate accelerations (kobs/k uncat > 104) in the thiolysis reaction of complementary barbiturate acetate derivatives.

Original languageEnglish (US)
Pages (from-to)1232-1234
Number of pages3
JournalJournal of the Chemical Society, Chemical Communications
Issue number18
DOIs
StatePublished - Dec 1 1990

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ASJC Scopus subject areas

  • Molecular Medicine

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