Molecular ping-pong Game of Life on a two-dimensional DNA origami array

N. Jonoska, Nadrian Seeman

Research output: Contribution to journalArticle

Abstract

We propose a design for programmed molecular interactions that continuously change molecular arrangements in a predesigned manner. We introduce a model where environmental control through laser illumination allows platform attachment/detachment oscillations between two floating molecular species. The platform is a two-dimensional DNA origami array of tiles decorated with strands that provide both, the floating molecular tiles to attach and to pass communicating signals to neighbouring array tiles. In particular, we show how algorithmic molecular interactions can control cyclic molecular arrangements by exhibiting a system that can simulate the dynamics similar to two-dimensional cellular automata on a DNA origami array platform.

Original languageEnglish (US)
Article number20140215
JournalPhilosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Volume373
Issue number2046
DOIs
StatePublished - Jul 28 2015

Fingerprint

Game of Life
tiles
games
Tile
DNA
Molecular interactions
deoxyribonucleic acid
platforms
molecular interactions
floating
Arrangement
environmental control
communicating
cellular automata
Cellular automata
Interaction
detachment
strands
Cellular Automata
attachment

Keywords

  • Cellular automata
  • DNA origami
  • DNA signals
  • Game of Life
  • Laser illumination assembly control
  • Oscillating DNA attachments

ASJC Scopus subject areas

  • Mathematics(all)
  • Physics and Astronomy(all)
  • Engineering(all)

Cite this

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