Molecular mechanisms underlying a unique intermediate phase of memory in Aplysia

Michael A. Sutton, Sarah E. Masters, Martha W. Bagnall, Thomas Carew

Research output: Contribution to journalArticle

Abstract

Short- and long-term synaptic facilitation induced by serotonin at Aplysia sensory-motor (SN-MN) synapses has been widely used as a cellular model of short- and long-term memory for sensitization. In recent years, a distinct intermediate phase of synaptic facilitation (ITF) has been described at SN-MN synapses. Here, we identify a novel intermediate phase of behavioral memory (ITM) for sensitization in Aplysia and demonstrate that it shares the temporal and mechanistic features of ITF in the intact CNS: (1) it declines completely prior to the onset of LTM, (2) its induction requires protein but not RNA synthesis, and (3) its expression requires the persistent activation of protein kinase A. Thus, in Aplysia, the same temporal and molecular characteristics that distinguish ITF from other phases of synaptic plasticity distinguish ITM from other phases of behavioral memory.

Original languageEnglish (US)
Pages (from-to)143-154
Number of pages12
JournalNeuron
Volume31
Issue number1
DOIs
StatePublished - 2001

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Aplysia
Synapses
Neuronal Plasticity
Long-Term Memory
Cyclic AMP-Dependent Protein Kinases
Serotonin
RNA
Proteins

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molecular mechanisms underlying a unique intermediate phase of memory in Aplysia. / Sutton, Michael A.; Masters, Sarah E.; Bagnall, Martha W.; Carew, Thomas.

In: Neuron, Vol. 31, No. 1, 2001, p. 143-154.

Research output: Contribution to journalArticle

Sutton, Michael A. ; Masters, Sarah E. ; Bagnall, Martha W. ; Carew, Thomas. / Molecular mechanisms underlying a unique intermediate phase of memory in Aplysia. In: Neuron. 2001 ; Vol. 31, No. 1. pp. 143-154.
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