Molecular mechanisms of threat learning in the lateral nucleus of the amygdala

Robert M. Sears, Hillary C. Schiff, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Pavlovian threat conditioning is a behavioral paradigm that has been successfully utilized to define the mechanisms underlying threat (fear) memory formation. The amygdala is a temporal lobe structure required for the acquisition, consolidation, and expression of threat (fear) memories. In particular, the lateral nucleus of the amygdala (LA) is the major input structure of the amygdala and is required for all aspects of threat learning and memory. The LA expresses many neurotransmitter and neuromodulator receptors. This chapter covers the molecular mechanisms that occur downstream of these receptors and how they influence LA-dependent Pavlovian threat learning.

Original languageEnglish (US)
Pages (from-to)263-304
Number of pages42
JournalProgress in Molecular Biology and Translational Science
Volume122
DOIs
StatePublished - 2014

Fingerprint

Neurotransmitter Receptor
Learning
Amygdala
Fear
Temporal Lobe
Basolateral Nuclear Complex
Conditioning (Psychology)

Keywords

  • Acquisition
  • Amygdala
  • Consolidation
  • Fear conditioning
  • Molecular mechanisms
  • Plasticity
  • Signaling pathways
  • Threat conditioning

ASJC Scopus subject areas

  • Molecular Biology
  • Molecular Medicine

Cite this

Molecular mechanisms of threat learning in the lateral nucleus of the amygdala. / Sears, Robert M.; Schiff, Hillary C.; Ledoux, Joseph.

In: Progress in Molecular Biology and Translational Science, Vol. 122, 2014, p. 263-304.

Research output: Contribution to journalArticle

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