Molecular machines

Research output: Contribution to journalReview article

Abstract

Molecular machines (MM) are essential components of living cells. They conduct mechanical work, transport materials into and out of cells, assist in processing enzymatic reactions, and more. Their operations are frequently combined with significant conformational transitions. Computational studies of these conformational transitions and their coupling to molecular functions are discussed. It is argued that coarse descriptions of these molecules which are based on mass density and shape provide useful information on directions of action. It is further argued that MM are likely to have well focused and narrow reaction pathways. The proposal for such pathways is supported by evolutionary analyses of homologous machines. Finally, these observations are used to build atomically detailed models of these systems that are making the link from structure to functions (kinetics and thermodynamics). For that purpose enhanced sampling techniques are required.

Original languageEnglish (US)
Pages (from-to)206-211
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume23
Issue number2
DOIs
StatePublished - Apr 1 2013

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Cellular Structures
Thermodynamics
Direction compound

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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Molecular machines. / Elber, Ron; Kirmizialtin, Serdal.

In: Current Opinion in Structural Biology, Vol. 23, No. 2, 01.04.2013, p. 206-211.

Research output: Contribution to journalReview article

Elber, Ron ; Kirmizialtin, Serdal. / Molecular machines. In: Current Opinion in Structural Biology. 2013 ; Vol. 23, No. 2. pp. 206-211.
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