Molecular evolution of the ψη-globin gene locus: Gibbon phylogeny and the hominoid slowdown

Wendy J. Bailey, David Fitch, Danilo A. Tagle, John Czelusniak, Jerry L. Slightom, Morris Goodman

Research output: Contribution to journalArticle

Abstract

An 8.4-kb genomic region spanning both the ψη-globin gene locus and flanking DNA was sequenced from the common gibbon (Hylobates lar). In addition, sequencing of the entire orthologous region from galago (Galago crassicaudatus) was completed. The gibbon and galago sequences, along with published orthologous sequences from 10 other species, were aligned. These noncoding nucleotide sequences represented four human alleles, four apes (chimpanzee, gorilla, orangutan, and gibbon), an Old World monkey (rhesus monkey), two New World monkeys (spider and owl monkeys), tarsier, two strepsirhines (galago and lemur), and goat. Divergence and maximum parsimony analyses of the ψη genomic region first groups humans and chimpanzees and then, at progressively more ancient branch points, successively joins gorillas, orangutans, gibbons, Old World monkeys, New World monkeys, tarsiers, and strepsirhines (the lemuriform-lorisiform branch of primates). This cladistic pattern supports the taxonomic grouping of all extant hominoids into family Hominidae, the division of Hominidae into subfamilies Hylobatinae (gibbons) and Homininae, the division of Homininae into tribes Pongini (orangutans) and Hominini, and the division of Hominini into subtribes Gorillina (gorillas) and Hominina (chimpanzees and humans). The additional gibbon and galago sequence data provide further support for the occurrence of a graded evolutionaryrate slowdown in the descent of simian primates, with the slowing rate being more pronounced in the great-ape and human lineages than in the gibbon or monkey lineages. A comparison of global versus local molecular clocks reveals that local clock predictions, when focused on a specific number of species within a narrow time frame, provide a more accurate estimate of divergence dates than do those of global clocks.

Original languageEnglish (US)
Pages (from-to)155-184
Number of pages30
JournalMolecular Biology and Evolution
Volume8
Issue number2
StatePublished - Mar 1991

Fingerprint

Hylobates
Hylobatidae
Globins
Molecular Evolution
Hominidae
Phylogeny
Galago
Clocks
phylogeny
Genes
primate
loci
gene
genomics
Pongo
Pongo pygmaeus
divergence
Tarsiidae
Pan troglodytes
genes

Keywords

  • ψη-globin gene
  • Cladistic classification
  • DNA hybridization
  • Maximum parsimony
  • Noncoding nucleotide sequences
  • Primate phylogeny

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Genetics(clinical)

Cite this

Bailey, W. J., Fitch, D., Tagle, D. A., Czelusniak, J., Slightom, J. L., & Goodman, M. (1991). Molecular evolution of the ψη-globin gene locus: Gibbon phylogeny and the hominoid slowdown. Molecular Biology and Evolution, 8(2), 155-184.

Molecular evolution of the ψη-globin gene locus : Gibbon phylogeny and the hominoid slowdown. / Bailey, Wendy J.; Fitch, David; Tagle, Danilo A.; Czelusniak, John; Slightom, Jerry L.; Goodman, Morris.

In: Molecular Biology and Evolution, Vol. 8, No. 2, 03.1991, p. 155-184.

Research output: Contribution to journalArticle

Bailey, WJ, Fitch, D, Tagle, DA, Czelusniak, J, Slightom, JL & Goodman, M 1991, 'Molecular evolution of the ψη-globin gene locus: Gibbon phylogeny and the hominoid slowdown', Molecular Biology and Evolution, vol. 8, no. 2, pp. 155-184.
Bailey, Wendy J. ; Fitch, David ; Tagle, Danilo A. ; Czelusniak, John ; Slightom, Jerry L. ; Goodman, Morris. / Molecular evolution of the ψη-globin gene locus : Gibbon phylogeny and the hominoid slowdown. In: Molecular Biology and Evolution. 1991 ; Vol. 8, No. 2. pp. 155-184.
@article{aa7be62e8878497295f9a050d682c1bb,
title = "Molecular evolution of the ψη-globin gene locus: Gibbon phylogeny and the hominoid slowdown",
abstract = "An 8.4-kb genomic region spanning both the ψη-globin gene locus and flanking DNA was sequenced from the common gibbon (Hylobates lar). In addition, sequencing of the entire orthologous region from galago (Galago crassicaudatus) was completed. The gibbon and galago sequences, along with published orthologous sequences from 10 other species, were aligned. These noncoding nucleotide sequences represented four human alleles, four apes (chimpanzee, gorilla, orangutan, and gibbon), an Old World monkey (rhesus monkey), two New World monkeys (spider and owl monkeys), tarsier, two strepsirhines (galago and lemur), and goat. Divergence and maximum parsimony analyses of the ψη genomic region first groups humans and chimpanzees and then, at progressively more ancient branch points, successively joins gorillas, orangutans, gibbons, Old World monkeys, New World monkeys, tarsiers, and strepsirhines (the lemuriform-lorisiform branch of primates). This cladistic pattern supports the taxonomic grouping of all extant hominoids into family Hominidae, the division of Hominidae into subfamilies Hylobatinae (gibbons) and Homininae, the division of Homininae into tribes Pongini (orangutans) and Hominini, and the division of Hominini into subtribes Gorillina (gorillas) and Hominina (chimpanzees and humans). The additional gibbon and galago sequence data provide further support for the occurrence of a graded evolutionaryrate slowdown in the descent of simian primates, with the slowing rate being more pronounced in the great-ape and human lineages than in the gibbon or monkey lineages. A comparison of global versus local molecular clocks reveals that local clock predictions, when focused on a specific number of species within a narrow time frame, provide a more accurate estimate of divergence dates than do those of global clocks.",
keywords = "ψη-globin gene, Cladistic classification, DNA hybridization, Maximum parsimony, Noncoding nucleotide sequences, Primate phylogeny",
author = "Bailey, {Wendy J.} and David Fitch and Tagle, {Danilo A.} and John Czelusniak and Slightom, {Jerry L.} and Morris Goodman",
year = "1991",
month = "3",
language = "English (US)",
volume = "8",
pages = "155--184",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "2",

}

TY - JOUR

T1 - Molecular evolution of the ψη-globin gene locus

T2 - Gibbon phylogeny and the hominoid slowdown

AU - Bailey, Wendy J.

AU - Fitch, David

AU - Tagle, Danilo A.

AU - Czelusniak, John

AU - Slightom, Jerry L.

AU - Goodman, Morris

PY - 1991/3

Y1 - 1991/3

N2 - An 8.4-kb genomic region spanning both the ψη-globin gene locus and flanking DNA was sequenced from the common gibbon (Hylobates lar). In addition, sequencing of the entire orthologous region from galago (Galago crassicaudatus) was completed. The gibbon and galago sequences, along with published orthologous sequences from 10 other species, were aligned. These noncoding nucleotide sequences represented four human alleles, four apes (chimpanzee, gorilla, orangutan, and gibbon), an Old World monkey (rhesus monkey), two New World monkeys (spider and owl monkeys), tarsier, two strepsirhines (galago and lemur), and goat. Divergence and maximum parsimony analyses of the ψη genomic region first groups humans and chimpanzees and then, at progressively more ancient branch points, successively joins gorillas, orangutans, gibbons, Old World monkeys, New World monkeys, tarsiers, and strepsirhines (the lemuriform-lorisiform branch of primates). This cladistic pattern supports the taxonomic grouping of all extant hominoids into family Hominidae, the division of Hominidae into subfamilies Hylobatinae (gibbons) and Homininae, the division of Homininae into tribes Pongini (orangutans) and Hominini, and the division of Hominini into subtribes Gorillina (gorillas) and Hominina (chimpanzees and humans). The additional gibbon and galago sequence data provide further support for the occurrence of a graded evolutionaryrate slowdown in the descent of simian primates, with the slowing rate being more pronounced in the great-ape and human lineages than in the gibbon or monkey lineages. A comparison of global versus local molecular clocks reveals that local clock predictions, when focused on a specific number of species within a narrow time frame, provide a more accurate estimate of divergence dates than do those of global clocks.

AB - An 8.4-kb genomic region spanning both the ψη-globin gene locus and flanking DNA was sequenced from the common gibbon (Hylobates lar). In addition, sequencing of the entire orthologous region from galago (Galago crassicaudatus) was completed. The gibbon and galago sequences, along with published orthologous sequences from 10 other species, were aligned. These noncoding nucleotide sequences represented four human alleles, four apes (chimpanzee, gorilla, orangutan, and gibbon), an Old World monkey (rhesus monkey), two New World monkeys (spider and owl monkeys), tarsier, two strepsirhines (galago and lemur), and goat. Divergence and maximum parsimony analyses of the ψη genomic region first groups humans and chimpanzees and then, at progressively more ancient branch points, successively joins gorillas, orangutans, gibbons, Old World monkeys, New World monkeys, tarsiers, and strepsirhines (the lemuriform-lorisiform branch of primates). This cladistic pattern supports the taxonomic grouping of all extant hominoids into family Hominidae, the division of Hominidae into subfamilies Hylobatinae (gibbons) and Homininae, the division of Homininae into tribes Pongini (orangutans) and Hominini, and the division of Hominini into subtribes Gorillina (gorillas) and Hominina (chimpanzees and humans). The additional gibbon and galago sequence data provide further support for the occurrence of a graded evolutionaryrate slowdown in the descent of simian primates, with the slowing rate being more pronounced in the great-ape and human lineages than in the gibbon or monkey lineages. A comparison of global versus local molecular clocks reveals that local clock predictions, when focused on a specific number of species within a narrow time frame, provide a more accurate estimate of divergence dates than do those of global clocks.

KW - ψη-globin gene

KW - Cladistic classification

KW - DNA hybridization

KW - Maximum parsimony

KW - Noncoding nucleotide sequences

KW - Primate phylogeny

UR - http://www.scopus.com/inward/record.url?scp=0026034207&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026034207&partnerID=8YFLogxK

M3 - Article

C2 - 2046542

AN - SCOPUS:0026034207

VL - 8

SP - 155

EP - 184

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 2

ER -