Molecular design of inorganic-binding polypeptides

John Evans, Ram Samudrala, Tiffany R. Walsh, Ersin Emre Oren, Candan Tamerler

Research output: Contribution to journalArticle

Abstract

Controlled binding and assembly of peptides onto inorganic substrates is at the core of bionanotechnology and biological-materials engineering. Peptides offer several unique advantages for developing future inorganic materials and systems. First, engineered polypeptides can molecularly recognize inorganic surfaces that are distinguishable by shape, crystallography, mineralogy, and chemistry. Second, polypeptides are capable of self-assembly on specific material surfaces leading to addressable molecular architectures. Finally, genetically engineered peptides offer multiple strategies for their functional modification. In this article, we summarize the details and mechanisms involved in combinatorial-polypeptide sequence selection and inorganic-material recognition and affinity, and outline experimental and theoretical approaches and concepts that will help advance this emerging field.

Original languageEnglish (US)
Pages (from-to)514-518
Number of pages5
JournalMRS Bulletin
Volume33
Issue number5
StatePublished - May 2008

Fingerprint

Polypeptides
polypeptides
Peptides
peptides
inorganic materials
Crystallography
Mineralogy
mineralogy
Biological materials
Self assembly
crystallography
affinity
self assembly
emerging
assembly
engineering
chemistry
Substrates

ASJC Scopus subject areas

  • Materials Science(all)
  • Physics and Astronomy (miscellaneous)

Cite this

Evans, J., Samudrala, R., Walsh, T. R., Oren, E. E., & Tamerler, C. (2008). Molecular design of inorganic-binding polypeptides. MRS Bulletin, 33(5), 514-518.

Molecular design of inorganic-binding polypeptides. / Evans, John; Samudrala, Ram; Walsh, Tiffany R.; Oren, Ersin Emre; Tamerler, Candan.

In: MRS Bulletin, Vol. 33, No. 5, 05.2008, p. 514-518.

Research output: Contribution to journalArticle

Evans, J, Samudrala, R, Walsh, TR, Oren, EE & Tamerler, C 2008, 'Molecular design of inorganic-binding polypeptides', MRS Bulletin, vol. 33, no. 5, pp. 514-518.
Evans J, Samudrala R, Walsh TR, Oren EE, Tamerler C. Molecular design of inorganic-binding polypeptides. MRS Bulletin. 2008 May;33(5):514-518.
Evans, John ; Samudrala, Ram ; Walsh, Tiffany R. ; Oren, Ersin Emre ; Tamerler, Candan. / Molecular design of inorganic-binding polypeptides. In: MRS Bulletin. 2008 ; Vol. 33, No. 5. pp. 514-518.
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