Molecular and genetic damage in humans from environmental pollution in Poland

Frederica P. Perera, Kari Hemminkit, Ewa Gryzbowska, Grazyna Motykiewkz, Jadwiga Michalska, Regina M. Santella, Tie Lan Young, Chris Dickey, Paul Brandt-Rauf, Immaculata DeVivo, William Blaner, Wei Yann Tsai, Mieczyslaw Chorazy

Research output: Contribution to journalArticle

Abstract

EXTREME environmental pollution such as that found in the highly industrialized Silesian region of Poland has been associated with increased risk of cancer and adverse reproductive outcomes1,2. Among the most prevalent carcinogenic and mutagenic air poll-utants in Silesia are the polycyclic aromatic hydrocarbons (PAH) which are largely produced by industrial and residential combustion of coal1. Molecular epidemiology aims to prevent disease by using biological markers to identify risks well before clinical onset to allow effective intervention3-7. Here, we use a battery of biological markers to measure molecular and genetic damage in peripheral blood samples from residents of Silesia and from persons living in a rural, less polluted area of Poland. The results show that their exposure to environmental pollution is associated with significant increases in carcinogen-DNA adducts (PAH-DNA and aromatic adducts), in sister chromatid exchange includ-ing high-frequency cells, and in chromosomal aberrations as well as a doubling in the frequency of ras oncogene overexpression. We found that aromatic adducts on DNA were significantly correlated with chromosomal mutation, providing us with a molecular link between environmental exposure and a genetic alteration relevant to cancer and reproductive risk.

Original languageEnglish (US)
Pages (from-to)256-258
Number of pages3
JournalNature
Volume360
Issue number6401
StatePublished - Nov 19 1992

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DNA
damage
cancer
PAH
Silesian
carcinogen
epidemiology
mutation
combustion
blood
air
environmental pollution
exposure
marker
battery

ASJC Scopus subject areas

  • General
  • Environmental Science(all)
  • Earth and Planetary Sciences(all)

Cite this

Perera, F. P., Hemminkit, K., Gryzbowska, E., Motykiewkz, G., Michalska, J., Santella, R. M., ... Chorazy, M. (1992). Molecular and genetic damage in humans from environmental pollution in Poland. Nature, 360(6401), 256-258.

Molecular and genetic damage in humans from environmental pollution in Poland. / Perera, Frederica P.; Hemminkit, Kari; Gryzbowska, Ewa; Motykiewkz, Grazyna; Michalska, Jadwiga; Santella, Regina M.; Young, Tie Lan; Dickey, Chris; Brandt-Rauf, Paul; DeVivo, Immaculata; Blaner, William; Tsai, Wei Yann; Chorazy, Mieczyslaw.

In: Nature, Vol. 360, No. 6401, 19.11.1992, p. 256-258.

Research output: Contribution to journalArticle

Perera, FP, Hemminkit, K, Gryzbowska, E, Motykiewkz, G, Michalska, J, Santella, RM, Young, TL, Dickey, C, Brandt-Rauf, P, DeVivo, I, Blaner, W, Tsai, WY & Chorazy, M 1992, 'Molecular and genetic damage in humans from environmental pollution in Poland', Nature, vol. 360, no. 6401, pp. 256-258.
Perera FP, Hemminkit K, Gryzbowska E, Motykiewkz G, Michalska J, Santella RM et al. Molecular and genetic damage in humans from environmental pollution in Poland. Nature. 1992 Nov 19;360(6401):256-258.
Perera, Frederica P. ; Hemminkit, Kari ; Gryzbowska, Ewa ; Motykiewkz, Grazyna ; Michalska, Jadwiga ; Santella, Regina M. ; Young, Tie Lan ; Dickey, Chris ; Brandt-Rauf, Paul ; DeVivo, Immaculata ; Blaner, William ; Tsai, Wei Yann ; Chorazy, Mieczyslaw. / Molecular and genetic damage in humans from environmental pollution in Poland. In: Nature. 1992 ; Vol. 360, No. 6401. pp. 256-258.
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