Modulation of two second messenger in bitter taste transduction of agriculturally relevant compounds

Andrew Spielman, W. Yan, V. Krizhanovsky, S. Rosenzweig, T. Yamamoto, M. Naim

Research output: Contribution to journalArticle

Abstract

The formation of chemical cellular signals in response to taste stimulation may be be initiated in sub-second time range. We are using a Quench Flow Module (QFM) and a Fast Pippeting System (FPS) to monitor cellular signals in rat taste tissue hemogenates ans intact cells in response to bitter taste stimulants that are important to the acceptance of agricultural food products. Stimulation by grape-derived catechin and the citurs-derived naringin increaesd the formation of the IP3 signal with parallel decline of cAMP. Under similar experimental conditions, the citrus-derived limonin reduced cAMP whereas casein-derived cyclo(Leu-Trp) bitter dipeptide produced a rapid and transient increase of cAMP. cGMP was not affected by any of the four stimuli. These results further emphasize the presence of multiple transduction pathways and modulation of two parallel second messengers in bitter taste sensation of some bitter compounds.

Original languageEnglish (US)
Pages (from-to)18-31
Number of pages14
JournalACS Symposium Series
Volume825
StatePublished - 2002

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Casein
Catechin
Dipeptides
Second Messenger Systems
Caseins
Rats
Modulation
Tissue
limonin
naringin
cyclo(L-leucyl-L-tryptophyl)

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

Spielman, A., Yan, W., Krizhanovsky, V., Rosenzweig, S., Yamamoto, T., & Naim, M. (2002). Modulation of two second messenger in bitter taste transduction of agriculturally relevant compounds. ACS Symposium Series, 825, 18-31.

Modulation of two second messenger in bitter taste transduction of agriculturally relevant compounds. / Spielman, Andrew; Yan, W.; Krizhanovsky, V.; Rosenzweig, S.; Yamamoto, T.; Naim, M.

In: ACS Symposium Series, Vol. 825, 2002, p. 18-31.

Research output: Contribution to journalArticle

Spielman, A, Yan, W, Krizhanovsky, V, Rosenzweig, S, Yamamoto, T & Naim, M 2002, 'Modulation of two second messenger in bitter taste transduction of agriculturally relevant compounds', ACS Symposium Series, vol. 825, pp. 18-31.
Spielman, Andrew ; Yan, W. ; Krizhanovsky, V. ; Rosenzweig, S. ; Yamamoto, T. ; Naim, M. / Modulation of two second messenger in bitter taste transduction of agriculturally relevant compounds. In: ACS Symposium Series. 2002 ; Vol. 825. pp. 18-31.
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