Modulation of neural commitment by changes in target cell contacts in Pleurodeles waltl

Jean-Pierre Saint-Jeannet, Song Huang, Anne Marie Duprat

Research output: Contribution to journalArticle

Abstract

In amphibian development, neural structures arise from the presumptive ectoderm at the gastrula stage by an inductive interaction with the chordamesoderm. It has been previously reported that early gastrula presumptive ectoderm can be neuralized when it is dissociated into single cells. A similar result is reported here with regard to Pleurodeles waltl presumptive ectoderm. Using this experimental model system we demonstrate: first, that neuronal and glial lineages can be specified from the presumptive ectoderm without any intervention of the natural inducing tissue; and second, that whereas rupture of cell-cell contacts evoked neural induction, dissociation immediately followed by reaggregation reduces the neuralizing response, pointing toward an active role played by cell-cell contacts of presumptive ectodermal cells in the modulation of neural commitment.

Original languageEnglish (US)
Pages (from-to)93-103
Number of pages11
JournalDevelopmental Biology
Volume141
Issue number1
DOIs
StatePublished - 1990

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Pleurodeles
Ectoderm
Gastrula
Notochord
Amphibians
Neuroglia
Rupture
Theoretical Models

ASJC Scopus subject areas

  • Developmental Biology

Cite this

Modulation of neural commitment by changes in target cell contacts in Pleurodeles waltl. / Saint-Jeannet, Jean-Pierre; Huang, Song; Duprat, Anne Marie.

In: Developmental Biology, Vol. 141, No. 1, 1990, p. 93-103.

Research output: Contribution to journalArticle

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