Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment

Jennifer W. Tidey, Peter M. Monti, Damaris J. Rohsenow, Chad J. Gwaltney, Robert Miranda, John E. McGeary, James MacKillop, Robert M. Swift, David Abrams, Saul Shiffman, Jean A. Paty

Research output: Contribution to journalArticle

Abstract

Background: Naltrexone (NTX) has proven to be effective with alcoholics in treatment, with most controlled clinical trials showing beneficial effects on heavy drinking rates. However, little is known about the behavioral mechanisms underlying the effects of NTX on drinking, or about patient characteristics that may moderate NTX's effects on drinking. In this study, ecological momentary assessment (EMA) techniques were used to investigate some of the putative mechanisms of naltrexone's effects on drinking in heavy drinkers who were not seeking treatment for alcohol problems. Polymorphisms in the D4 dopamine receptor (DRD4) gene and the μ-opiate receptor (OPRM1) gene, family history of alcohol problems, age of onset of alcoholism and gender were explored as potential moderators of NTX's effects. Methods: After a 1-week placebo lead-in period, heavy drinkers (n = 180), 63% of whom were alcohol-dependent, were randomized to 3 weeks of daily naltrexone (50 mg) or placebo. Throughout the study, participants used EMA on palm-pilot computers to enter, in real time, drink data, urge levels, and subjective effects of alcohol consumption. Results: Naltrexone reduced percentage drinking days in all participants and reduced percent heavy drinking days in DRD4-L individuals; NTX decreased urge levels in participants with younger age of alcoholism onset; NTX increased time between drinks in participants who had more relatives with alcohol problems; and NTX reduced the stimulating effects of alcohol in women. OPRM1 status did not moderate any of NTX's effects. Conclusions: These results confirm earlier findings of NTX's effects on drinking and related subjective effects, and extend them by describing individual difference variables that moderate these effects in the natural environment, using data collected in real time.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Volume32
Issue number1
DOIs
StatePublished - Jan 2008

Fingerprint

Naltrexone
Moderators
Alcohol Drinking
Drinking
Alcohols
Age of Onset
Alcoholism
Genes
Placebos
Dopamine D4 Receptors
Handheld Computers
Controlled Clinical Trials
Opioid Receptors
Alcoholics
Polymorphism
Individuality
Therapeutics

Keywords

  • Family History
  • Genetics
  • Naltrexone
  • Pharmacology
  • Treatment

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health

Cite this

Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment. / Tidey, Jennifer W.; Monti, Peter M.; Rohsenow, Damaris J.; Gwaltney, Chad J.; Miranda, Robert; McGeary, John E.; MacKillop, James; Swift, Robert M.; Abrams, David; Shiffman, Saul; Paty, Jean A.

In: Alcoholism: Clinical and Experimental Research, Vol. 32, No. 1, 01.2008, p. 58-66.

Research output: Contribution to journalArticle

Tidey, Jennifer W. ; Monti, Peter M. ; Rohsenow, Damaris J. ; Gwaltney, Chad J. ; Miranda, Robert ; McGeary, John E. ; MacKillop, James ; Swift, Robert M. ; Abrams, David ; Shiffman, Saul ; Paty, Jean A. / Moderators of naltrexone's effects on drinking, urge, and alcohol effects in non-treatment-seeking heavy drinkers in the natural environment. In: Alcoholism: Clinical and Experimental Research. 2008 ; Vol. 32, No. 1. pp. 58-66.
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abstract = "Background: Naltrexone (NTX) has proven to be effective with alcoholics in treatment, with most controlled clinical trials showing beneficial effects on heavy drinking rates. However, little is known about the behavioral mechanisms underlying the effects of NTX on drinking, or about patient characteristics that may moderate NTX's effects on drinking. In this study, ecological momentary assessment (EMA) techniques were used to investigate some of the putative mechanisms of naltrexone's effects on drinking in heavy drinkers who were not seeking treatment for alcohol problems. Polymorphisms in the D4 dopamine receptor (DRD4) gene and the μ-opiate receptor (OPRM1) gene, family history of alcohol problems, age of onset of alcoholism and gender were explored as potential moderators of NTX's effects. Methods: After a 1-week placebo lead-in period, heavy drinkers (n = 180), 63{\%} of whom were alcohol-dependent, were randomized to 3 weeks of daily naltrexone (50 mg) or placebo. Throughout the study, participants used EMA on palm-pilot computers to enter, in real time, drink data, urge levels, and subjective effects of alcohol consumption. Results: Naltrexone reduced percentage drinking days in all participants and reduced percent heavy drinking days in DRD4-L individuals; NTX decreased urge levels in participants with younger age of alcoholism onset; NTX increased time between drinks in participants who had more relatives with alcohol problems; and NTX reduced the stimulating effects of alcohol in women. OPRM1 status did not moderate any of NTX's effects. Conclusions: These results confirm earlier findings of NTX's effects on drinking and related subjective effects, and extend them by describing individual difference variables that moderate these effects in the natural environment, using data collected in real time.",
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AU - Miranda, Robert

AU - McGeary, John E.

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