Models of membrane resonance in pigeon semicircular canal type II hair cells

Dora Angelaki, M. J. Correia

Research output: Contribution to journalArticle

Abstract

Pigeon vestibular semicircular canal type II hair cells often exhibit voltage oscillations following current steps that depolarize the cell membrane from its resting potential. Currents active around the resting membrane potential and most likely responsible for the observed resonant behavior are the Ca++-insensitive, inactivating potassium conductance IA (A-current) and delayed rectifier potassium conductance IK. Several equivalent circuits are considered as representative of the hair cell membrane behavior, sufficient to explain and quantitatively fit the observed voltage oscillations. In addition to the membrane capacitance and frequency-independent parallel conductance, a third parallel element whose admittance function is of second order is necessary to describe and accurately predict all of the experimentally obtained current and voltage responses. Even though most voltage oscillations could be fitted by an equivalent circuit in which the second order admittance term is overdamped (i.e., represents a type of current with two time constants, one of activation and the other of inactivation), the sharpest quality resonance obtained with small current steps (around 20 pA) from the resting potential could be satisfactorily fit only by an underdamped term.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalBiological Cybernetics
Volume65
Issue number1
DOIs
StatePublished - May 1 1991

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Semicircular Canals
Columbidae
Canals
Membrane Potentials
Cells
Membranes
Potassium
Electric potential
Cell membranes
Cell Membrane
Equivalent circuits
Capacitance
Chemical activation

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science(all)

Cite this

Models of membrane resonance in pigeon semicircular canal type II hair cells. / Angelaki, Dora; Correia, M. J.

In: Biological Cybernetics, Vol. 65, No. 1, 01.05.1991, p. 1-10.

Research output: Contribution to journalArticle

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