Modeling the conductance and DNA blockade of solid-state nanopores

Stefan W. Kowalczyk, Alexander Y. Grosberg, Yitzhak Rabin, Cees Dekker

    Research output: Contribution to journalArticle

    Abstract

    We present measurements and theoretical modeling of the ionic conductance G of solid-state nanopores with 5-100nm diameters, with and without DNA inserted into the pore. First, we show that it is essential to include access resistance to describe the conductance, in particular for larger pore diameters. We then present an exact solution for G of an hourglass-shaped pore, which agrees very well with our measurements without any adjustable parameters, and which is an improvement over the cylindrical approximation. Subsequently we discuss the conductance blockade ΔG due to the insertion of a DNA molecule into the pore, which we study experimentally as a function of pore diameter. We find that ΔG decreases with pore diameter, contrary to the predictions of earlier models that forecasted a constant ΔG. We compare three models for ΔG, all of which provide good agreement with our experimental data.

    Original languageEnglish (US)
    Article number315101
    JournalNanotechnology
    Volume22
    Issue number31
    DOIs
    StatePublished - Aug 5 2011

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    Nanopores
    DNA
    Molecules
    Suby's G solution

    ASJC Scopus subject areas

    • Bioengineering
    • Chemistry(all)
    • Electrical and Electronic Engineering
    • Mechanical Engineering
    • Mechanics of Materials
    • Materials Science(all)

    Cite this

    Kowalczyk, S. W., Grosberg, A. Y., Rabin, Y., & Dekker, C. (2011). Modeling the conductance and DNA blockade of solid-state nanopores. Nanotechnology, 22(31), [315101]. https://doi.org/10.1088/0957-4484/22/31/315101

    Modeling the conductance and DNA blockade of solid-state nanopores. / Kowalczyk, Stefan W.; Grosberg, Alexander Y.; Rabin, Yitzhak; Dekker, Cees.

    In: Nanotechnology, Vol. 22, No. 31, 315101, 05.08.2011.

    Research output: Contribution to journalArticle

    Kowalczyk, SW, Grosberg, AY, Rabin, Y & Dekker, C 2011, 'Modeling the conductance and DNA blockade of solid-state nanopores', Nanotechnology, vol. 22, no. 31, 315101. https://doi.org/10.1088/0957-4484/22/31/315101
    Kowalczyk, Stefan W. ; Grosberg, Alexander Y. ; Rabin, Yitzhak ; Dekker, Cees. / Modeling the conductance and DNA blockade of solid-state nanopores. In: Nanotechnology. 2011 ; Vol. 22, No. 31.
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