Modeling of inhomogeneous electromagnetic fields in the nervous system

a novel paradigm in understanding cell interactions, disease etiology and therapy

Jasmina Isakovic, Ian Dobbs-Dixon, Dipesh Chaudhury, Dinko Mitrecic

    Research output: Contribution to journalArticle

    Abstract

    All major processes in the nervous system depend on interactions between cells and nerve fibers. In this work we present a novel model of inhomogeneous electromagnetic fields originating from nerve fibers and delineate their influence on cells. By expanding Hodgkin-Huxley’s applied current into axial current, governed byJij+1=K×Jij, we reveal that cell-with-neuron interactions are regulated by the strength of the electromagnetic fields, which are homogeneous up to 2.066 μm or 6.606 μm away from neurilemma and axolemma, respectively. At the nodes of Ranvier, these fields reach strengths of 3.0 × 10−12T, while at the myelinated segments they only peak at 2.3 × 10−12T. These are the same fields which are, due to inhomogeneity, detected as 1,000 times weaker by magnetoencephalography. Considering the widespread occurrence of neurodegenerative disorders, our model reveals that a 50% demyelination increases the field strength by 0.35 × 10−12T, while a complete demyelination increases it by 0.7 × 10−12T. Since this suggests that the inhomogeneous electromagnetic fields around neurons play a role in physiological and pathological processes, including cell-to-neuron and cell-to-cell communication, their improved understanding opens up new therapeutic strategies based on electromagnetic field modulation or cell’s surface charge alteration.

    Original languageEnglish (US)
    Article number12909
    JournalScientific Reports
    Volume8
    Issue number1
    DOIs
    StatePublished - Dec 1 2018

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    etiology
    nervous system
    therapy
    electromagnetic fields
    cells
    neurons
    nerve fibers
    interactions
    field strength
    inhomogeneity
    communication
    disorders
    occurrences
    modulation
    fibers

    ASJC Scopus subject areas

    • General

    Cite this

    Modeling of inhomogeneous electromagnetic fields in the nervous system : a novel paradigm in understanding cell interactions, disease etiology and therapy. / Isakovic, Jasmina; Dobbs-Dixon, Ian; Chaudhury, Dipesh; Mitrecic, Dinko.

    In: Scientific Reports, Vol. 8, No. 1, 12909, 01.12.2018.

    Research output: Contribution to journalArticle

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