Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy

Jasmina Isakovic, Ian Dobbs-Dixon, Dipesh Chaudhury, Dinko Mitrecic

Research output: Contribution to journalArticle

Abstract

All major processes in the nervous system depend on interactions between cells and nerve fibers. In this work we present a novel model of inhomogeneous electromagnetic fields originating from nerve fibers and delineate their influence on cells. By expanding Hodgkin-Huxley’s applied current into axial current, governed byJij+1=K×Jij, we reveal that cell-with-neuron interactions are regulated by the strength of the electromagnetic fields, which are homogeneous up to 2.066 μm or 6.606 μm away from neurilemma and axolemma, respectively. At the nodes of Ranvier, these fields reach strengths of 3.0 × 10−12T, while at the myelinated segments they only peak at 2.3 × 10−12T. These are the same fields which are, due to inhomogeneity, detected as 1,000 times weaker by magnetoencephalography. Considering the widespread occurrence of neurodegenerative disorders, our model reveals that a 50% demyelination increases the field strength by 0.35 × 10−12T, while a complete demyelination increases it by 0.7 × 10−12T. Since this suggests that the inhomogeneous electromagnetic fields around neurons play a role in physiological and pathological processes, including cell-to-neuron and cell-to-cell communication, their improved understanding opens up new therapeutic strategies based on electromagnetic field modulation or cell’s surface charge alteration.

Original languageEnglish (US)
Article number12909
JournalScientific Reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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etiology
nervous system
therapy
electromagnetic fields
cells
neurons
nerve fibers
interactions
field strength
inhomogeneity
communication
disorders
occurrences
modulation
fibers

ASJC Scopus subject areas

  • General

Cite this

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title = "Modeling of inhomogeneous electromagnetic fields in the nervous system: a novel paradigm in understanding cell interactions, disease etiology and therapy",
abstract = "All major processes in the nervous system depend on interactions between cells and nerve fibers. In this work we present a novel model of inhomogeneous electromagnetic fields originating from nerve fibers and delineate their influence on cells. By expanding Hodgkin-Huxley’s applied current into axial current, governed byJij+1=K×Jij, we reveal that cell-with-neuron interactions are regulated by the strength of the electromagnetic fields, which are homogeneous up to 2.066 μm or 6.606 μm away from neurilemma and axolemma, respectively. At the nodes of Ranvier, these fields reach strengths of 3.0 × 10−12T, while at the myelinated segments they only peak at 2.3 × 10−12T. These are the same fields which are, due to inhomogeneity, detected as 1,000 times weaker by magnetoencephalography. Considering the widespread occurrence of neurodegenerative disorders, our model reveals that a 50{\%} demyelination increases the field strength by 0.35 × 10−12T, while a complete demyelination increases it by 0.7 × 10−12T. Since this suggests that the inhomogeneous electromagnetic fields around neurons play a role in physiological and pathological processes, including cell-to-neuron and cell-to-cell communication, their improved understanding opens up new therapeutic strategies based on electromagnetic field modulation or cell’s surface charge alteration.",
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