Modeling cellular processes in 3D

Alex Mogilner, David Odde

Research output: Contribution to journalArticle

Abstract

Recent advances in photonic imaging and fluorescent protein technology offer unprecedented views of molecular space-time dynamics in living cells. At the same time, advances in computing hardware and software enable modeling of ever more complex systems, from global climate to cell division. As modeling and experiment become more closely integrated we must address the issue of modeling cellular processes in 3D. Here, we highlight recent advances related to 3D modeling in cell biology. While some processes require full 3D analysis, we suggest that others are more naturally described in 2D or 1D. Keeping the dimensionality as low as possible reduces computational time and makes models more intuitively comprehensible; however, the ability to test full 3D models will build greater confidence in models generally and remains an important emerging area of cell biological modeling.

Original languageEnglish (US)
Pages (from-to)692-700
Number of pages9
JournalTrends in Cell Biology
Volume21
Issue number12
DOIs
StatePublished - Dec 2011

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Optics and Photonics
Climate
Cell Division
Cell Biology
Software
Technology
Proteins

ASJC Scopus subject areas

  • Cell Biology

Cite this

Modeling cellular processes in 3D. / Mogilner, Alex; Odde, David.

In: Trends in Cell Biology, Vol. 21, No. 12, 12.2011, p. 692-700.

Research output: Contribution to journalArticle

Mogilner, Alex ; Odde, David. / Modeling cellular processes in 3D. In: Trends in Cell Biology. 2011 ; Vol. 21, No. 12. pp. 692-700.
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