Modeling and design of peptidomimetics to modulate protein–protein interactions

Andrew M. Watkins, Richard Bonneau, Paramjit Arora

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

We describe a modular approach to identify and inhibit protein–protein interactions (PPIs) that are mediated by protein secondary and tertiary structures with rationally designed peptidomimetics. Our analysis begins with entries of high-resolution complexes in the Protein Data Bank and utilizes conformational sampling, scoring, and design capabilities of advanced biomolecular modeling software to develop peptidomimetics.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
PublisherHumana Press Inc.
Pages291-307
Number of pages17
Volume1561
DOIs
StatePublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1561
ISSN (Print)10643745

Fingerprint

Peptidomimetics
Secondary Protein Structure
Tertiary Protein Structure
Software
Databases
Proteins

Keywords

  • Computational design
  • Inhibitor design
  • Peptidomimetics
  • Protein–protein interactions

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Watkins, A. M., Bonneau, R., & Arora, P. (2017). Modeling and design of peptidomimetics to modulate protein–protein interactions. In Methods in Molecular Biology (Vol. 1561, pp. 291-307). (Methods in Molecular Biology; Vol. 1561). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-6798-8_17

Modeling and design of peptidomimetics to modulate protein–protein interactions. / Watkins, Andrew M.; Bonneau, Richard; Arora, Paramjit.

Methods in Molecular Biology. Vol. 1561 Humana Press Inc., 2017. p. 291-307 (Methods in Molecular Biology; Vol. 1561).

Research output: Chapter in Book/Report/Conference proceedingChapter

Watkins, AM, Bonneau, R & Arora, P 2017, Modeling and design of peptidomimetics to modulate protein–protein interactions. in Methods in Molecular Biology. vol. 1561, Methods in Molecular Biology, vol. 1561, Humana Press Inc., pp. 291-307. https://doi.org/10.1007/978-1-4939-6798-8_17
Watkins AM, Bonneau R, Arora P. Modeling and design of peptidomimetics to modulate protein–protein interactions. In Methods in Molecular Biology. Vol. 1561. Humana Press Inc. 2017. p. 291-307. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-6798-8_17
Watkins, Andrew M. ; Bonneau, Richard ; Arora, Paramjit. / Modeling and design of peptidomimetics to modulate protein–protein interactions. Methods in Molecular Biology. Vol. 1561 Humana Press Inc., 2017. pp. 291-307 (Methods in Molecular Biology).
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