Model based conjectures on mammalian clock controversies

Daniel B. Forger, Charles Peskin

Research output: Contribution to journalArticle

Abstract

We explore some predictions of a previously developed detailed model of molecular timekeeping in mammals (Forger and Peskin, PNAS, 100:14806) in areas where our understanding of clock mechanisms are incomplete. It is conjectured that: (1) the clock's 24-h period depends on mRNA stability. (2) REV-ERBα suppresses and/or entrains rhythms in peripheral tissues by regulating CRY1 transcription. (3) CLK:BMAL1 oscillations are suppressed in the suprachiasmatic nuclei to enhance oscillations in other proteins. (4) PER2 is ineffective at causing phase advances because it is not induced by light during the late night. (5) The clock is a limit cycle oscillator that shows characteristics of the Evening and Morning oscillator model.

Original languageEnglish (US)
Pages (from-to)533-539
Number of pages7
JournalJournal of Theoretical Biology
Volume230
Issue number4 SPEC. ISS.
DOIs
StatePublished - Oct 21 2004

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Suprachiasmatic Nucleus
Molecular Models
RNA Stability
oscillation
Clocks
Mammals
Oscillation
Model-based
Light
molecular models
Limit Cycle
Messenger RNA
Transcription
Nucleus
Proteins
mammals
Protein
prediction
Prediction
Model

Keywords

  • BMAL Rev-erbα
  • Circadian Clock
  • CLOCK
  • CRY
  • Eukaryotic transcription regulation
  • Mathematical models
  • PER
  • Phase response curve

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Cite this

Model based conjectures on mammalian clock controversies. / Forger, Daniel B.; Peskin, Charles.

In: Journal of Theoretical Biology, Vol. 230, No. 4 SPEC. ISS., 21.10.2004, p. 533-539.

Research output: Contribution to journalArticle

Forger, Daniel B. ; Peskin, Charles. / Model based conjectures on mammalian clock controversies. In: Journal of Theoretical Biology. 2004 ; Vol. 230, No. 4 SPEC. ISS. pp. 533-539.
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