Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels

Shin Young Ryu, Gisela Beutner, Robert T. Dirksen, Kathleen W. Kinnally, Shey Shing Sheu

Research output: Contribution to journalArticle

Abstract

Ca2+ channels that underlie mitochondrial Ca2+ transport first reported decades ago have now just recently been precisely characterized electrophysiologically. Numerous data indicate that mitochondrial Ca2+ uptake via these channels regulates multiple intracellular processes by shaping cytosolic and mitochondrial Ca2+ transients, as well as altering the cellular metabolic and redox state. On the other hand, mitochondrial Ca2+ overload also initiates a cascade of events that leads to cell death. Thus, characterization of mitochondrial Ca2+ channels is central to a comprehensive understanding of cell signaling. Here, we discuss recent progresses in the biophysical and electrophysiological characterization of several distinct mitochondrial Ca2+ channels.

Original languageEnglish (US)
Pages (from-to)1948-1955
Number of pages8
JournalFEBS Letters
Volume584
Issue number10
DOIs
StatePublished - May 2010

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Ryanodine Receptor Calcium Release Channel
Oxidation-Reduction
Cell Death
Cell signaling
Cell death

Keywords

  • Ca channel
  • Mitochondrial Ca uniporter (MCU)
  • Mitochondrial ryanodine receptor (mRyR)
  • Rapid mode Ca uptake (RaM)
  • Ru360
  • Ruthenium red
  • Ryanodine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Genetics
  • Molecular Biology
  • Structural Biology

Cite this

Ryu, S. Y., Beutner, G., Dirksen, R. T., Kinnally, K. W., & Sheu, S. S. (2010). Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. FEBS Letters, 584(10), 1948-1955. https://doi.org/10.1016/j.febslet.2010.01.032

Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. / Ryu, Shin Young; Beutner, Gisela; Dirksen, Robert T.; Kinnally, Kathleen W.; Sheu, Shey Shing.

In: FEBS Letters, Vol. 584, No. 10, 05.2010, p. 1948-1955.

Research output: Contribution to journalArticle

Ryu, SY, Beutner, G, Dirksen, RT, Kinnally, KW & Sheu, SS 2010, 'Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels', FEBS Letters, vol. 584, no. 10, pp. 1948-1955. https://doi.org/10.1016/j.febslet.2010.01.032
Ryu, Shin Young ; Beutner, Gisela ; Dirksen, Robert T. ; Kinnally, Kathleen W. ; Sheu, Shey Shing. / Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. In: FEBS Letters. 2010 ; Vol. 584, No. 10. pp. 1948-1955.
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