Abstract
The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2142-2152 |
| Number of pages | 11 |
| Journal | FEBS Letters |
| Volume | 584 |
| Issue number | 10 |
| DOIs | |
| State | Published - May 2010 |
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Keywords
- Mitochondrial disease
- Mitochondrial ion channels
- Patch clamp
- Therapy
ASJC Scopus subject areas
- Biochemistry
- Biophysics
- Cell Biology
- Genetics
- Molecular Biology
- Structural Biology
Cite this
Mitochondrial ion channels as therapeutic targets. / Peixoto, Pablo M.; Ryu, Shin Young; Kinnally, Kathleen W.
In: FEBS Letters, Vol. 584, No. 10, 05.2010, p. 2142-2152.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mitochondrial ion channels as therapeutic targets
AU - Peixoto, Pablo M.
AU - Ryu, Shin Young
AU - Kinnally, Kathleen W.
PY - 2010/5
Y1 - 2010/5
N2 - The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.
AB - The study of mitochondrial ion channels changed our perception of these double-wrapped organelles from being just the power house of a cell to the guardian of a cell's fate. Mitochondria communicate with the cell through these special channels. Most of the time, the message is encoded by ion flow across the mitochondrial outer and inner membranes. Potassium, sodium, calcium, protons, nucleotides, and proteins traverse the mitochondrial membranes in an exquisitely regulated manner to control a myriad of processes, from respiration and mitochondrial morphology to cell proliferation and cell death. This review is an update on both well established and putative mitochondrial channels regarding their composition, function, regulation, and therapeutic potential.
KW - Mitochondrial disease
KW - Mitochondrial ion channels
KW - Patch clamp
KW - Therapy
UR - http://www.scopus.com/inward/record.url?scp=77952670367&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77952670367&partnerID=8YFLogxK
U2 - 10.1016/j.febslet.2010.02.046
DO - 10.1016/j.febslet.2010.02.046
M3 - Article
VL - 584
SP - 2142
EP - 2152
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 10
ER -