Mimicry of a β-Hairpin Turn by a Nonpeptidic Laterally Flexible Foldamer

Joseph W. Meisel, Chunhua T. Hu, Andrew Hamilton

Research output: Contribution to journalArticle


The design and characterization of a proteomimetic foldamer that displays lateral flexibility endowed by intramolecular bifurcated hydrogen bonds is reported. The MAMBA scaffold, derived from meta-aminomethylbenzoic acid, adopts a serpentine conformation that mimics the side chain projection of all four residues in a β-hairpin turn.

Original languageEnglish (US)
Pages (from-to)3879-3882
Number of pages4
JournalOrganic Letters
Issue number13
Publication statusPublished - Jul 6 2018


ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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