Microstructural disassembly of calcium phosphates

Haibo Wang, Jong Kook Lee, Amr Moursi, David Anderson, Phillip Winnard, Heather Powell, John Lannutti

Research output: Contribution to journalArticle

Abstract

Microstructural factors may play a role in the osseointegration of calcium phosphates. In this paper, direct microstructural interactions between crystalline calcium phosphates and the biological milieu are reported. Degradation via exposure to osteoblast culture closely resembles in vivo interactions with subcutaneous tissues in a bovine model at early time periods. That these interactions were common to both experiments constitutes one of the few known examples of in vitro-in vivo correspondence. Interestingly, the degradation of phase pure hydroxyapatite (HA) in vitro was more rapid than that of biphasic HA in vivo. In both cases, grain extraction/pullout was frequently observed. This suggests a connection to smaller-scale observations of epitaxial CHA nucleation and growth on pre-existing HA grains. A microstructure in which the grain boundary is dissolving/corroding can apparently be disassembled by forces transmitted through biological structures. These observations are distinct from those of simple non-biological solutions and prove that biological environments can interact with the material beneath the ceramic-cell/ceramic-tissue interface. Many often ignored microstructural factors-grain size, shape, grain boundary strength and the presence of impurity phases-may in fact control degradation. We also suggest that even relatively modest initial grain sizes will, in combination with the mild/absent foreign body response to calcium phosphates, result in lengthy in vivo particle resistence.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalJournal of Biomedical Materials Research - Part A
Volume68
Issue number1
StatePublished - Jan 1 2004

Fingerprint

Calcium Phosphates
Calcium phosphate
Durapatite
Hydroxyapatite
Degradation
Grain boundaries
Tissue
Osteoblasts
Cell culture
Nucleation
Impurities
Crystalline materials
Microstructure
Experiments

Keywords

  • Bioceramic
  • Ceramic
  • Corrosion
  • Intergranular
  • Oxide
  • Transgranular

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

Wang, H., Lee, J. K., Moursi, A., Anderson, D., Winnard, P., Powell, H., & Lannutti, J. (2004). Microstructural disassembly of calcium phosphates. Journal of Biomedical Materials Research - Part A, 68(1), 61-70.

Microstructural disassembly of calcium phosphates. / Wang, Haibo; Lee, Jong Kook; Moursi, Amr; Anderson, David; Winnard, Phillip; Powell, Heather; Lannutti, John.

In: Journal of Biomedical Materials Research - Part A, Vol. 68, No. 1, 01.01.2004, p. 61-70.

Research output: Contribution to journalArticle

Wang, H, Lee, JK, Moursi, A, Anderson, D, Winnard, P, Powell, H & Lannutti, J 2004, 'Microstructural disassembly of calcium phosphates', Journal of Biomedical Materials Research - Part A, vol. 68, no. 1, pp. 61-70.
Wang H, Lee JK, Moursi A, Anderson D, Winnard P, Powell H et al. Microstructural disassembly of calcium phosphates. Journal of Biomedical Materials Research - Part A. 2004 Jan 1;68(1):61-70.
Wang, Haibo ; Lee, Jong Kook ; Moursi, Amr ; Anderson, David ; Winnard, Phillip ; Powell, Heather ; Lannutti, John. / Microstructural disassembly of calcium phosphates. In: Journal of Biomedical Materials Research - Part A. 2004 ; Vol. 68, No. 1. pp. 61-70.
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