MicroRNA associated with dyslipidemia and coronary disease in humans

Elena Flowers, Bradley E. Aouizerat

Research output: Contribution to journalReview article

Abstract

MicroRNAs are structural components of an epigenetic mechanism of posttranscriptional regulation of messenger RNA translation. Recently, there has been significant interest in the application of microRNA as a blood-based biomarker of underlying physiological conditions. Dyslipidemia is a complex, heterogeneous condition conferring substantially increased risk for cardiovascular disease. The purpose of this review is to describe the current body of knowledge on the role of microRNA regulation of lipoprotein metabolism in humans and to discuss relevant methodological and study design considerations. We highlight the potential roles for microRNA in geneenvironment interactions.

Original languageEnglish (US)
Pages (from-to)1199-1205
Number of pages7
JournalPhysiological Genomics
Volume45
Issue number24
DOIs
StatePublished - Dec 15 2013

Keywords

  • Lipids
  • MicroRNA

ASJC Scopus subject areas

  • Physiology
  • Genetics

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