Microfluidic probes for use in life sciences and medicine

Mohammad Qasaimeh, Sébastien G. Ricoult, David Juncker

    Research output: Contribution to journalReview article

    Abstract

    Microfluidic probes (MFPs) combine the concepts of microfluidics and of scanning probes and constitute a contact-free and channel-free microfluidic system. Whereas classically the sample is introduced into the microfluidic device, with a MFP, the microfluidic stream is applied to the sample. MFPs use hydrodynamic flow confinement instead of walls to constrain a microfluidic stream between the MFP tip and a substrate. Because MFPs are free to move, they can be used to process large areas and samples in a selective manner. The development of MFP technology is recent and has numerous potential applications in several fields, most notably in the life sciences. In this review, we discuss the concept of MFPs and highlight their application in surface biopatterning, controlling the cellular microenvironments, local processing of tissue slices, and generating concentration gradients of biochemicals. We hope that this manuscript will serve as an interdisciplinary guide for both engineers as they further develop novel MFPs and applications and for life scientists who may identify novel uses of the MFP for their research.

    Original languageEnglish (US)
    Pages (from-to)40-45
    Number of pages6
    JournalLab on a Chip
    Volume13
    Issue number1
    DOIs
    StatePublished - Jan 7 2013

    Fingerprint

    Microfluidics
    Biological Science Disciplines
    Medicine
    Lab-On-A-Chip Devices
    Cellular Microenvironment
    Confined flow
    Hydrodynamics
    Contacts (fluid mechanics)

    ASJC Scopus subject areas

    • Bioengineering
    • Biochemistry
    • Chemistry(all)
    • Biomedical Engineering

    Cite this

    Qasaimeh, M., Ricoult, S. G., & Juncker, D. (2013). Microfluidic probes for use in life sciences and medicine. Lab on a Chip, 13(1), 40-45. https://doi.org/10.1039/c2lc40898h

    Microfluidic probes for use in life sciences and medicine. / Qasaimeh, Mohammad; Ricoult, Sébastien G.; Juncker, David.

    In: Lab on a Chip, Vol. 13, No. 1, 07.01.2013, p. 40-45.

    Research output: Contribution to journalReview article

    Qasaimeh, M, Ricoult, SG & Juncker, D 2013, 'Microfluidic probes for use in life sciences and medicine', Lab on a Chip, vol. 13, no. 1, pp. 40-45. https://doi.org/10.1039/c2lc40898h
    Qasaimeh, Mohammad ; Ricoult, Sébastien G. ; Juncker, David. / Microfluidic probes for use in life sciences and medicine. In: Lab on a Chip. 2013 ; Vol. 13, No. 1. pp. 40-45.
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