Methods for developmental studies of fear conditioning circuitry

Daniel S. Pine, Abby Fyer, Joseph Grun, Elizabeth Phelps, Philip R. Szeszko, Vivian Koda, Wei Li, Babak Ardekani, Eleanor A. Maguire, Neil Burgess, Robert M. Bilder

Research output: Contribution to journalArticle

Abstract

Psychophysiologic studies use air puff as an aversive stimulus to document abnormal fear conditioning in children of parents with anxiety disorders. This study used functional magnetic resonance imaging (fMRI) to examine changes in amygdala activity during air-puff conditioning among adults. Blood oxygen level-dependent (BOLD) signal was monitored in seven adults during 16 alternating presentations of two different colored lights (CS+ vs. CS-), one of which was consistently paired with an aversive air puff. A region-of-interest analysis demonstrated differential change in BOLD signal in the right but not left amygdala across CS+ versus CS- viewing. The amygdala is engaged by pairing of a light with an air puff. Given that prior studies relate air-puff conditioning to risk for anxiety in children, these methods may provide an avenue for directly studying the developmental neurobiology of fear conditioning.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalBiological Psychiatry
Volume50
Issue number3
DOIs
StatePublished - Aug 1 2001

Fingerprint

Amygdala
Air Conditioning
Fear
Air
Oxygen
Light
Neurobiology
Anxiety Disorders
Anxiety
Parents
Magnetic Resonance Imaging
Conditioning (Psychology)

Keywords

  • Anxiety
  • Development
  • Fear conditioning
  • FMRI
  • Neuroscience

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Pine, D. S., Fyer, A., Grun, J., Phelps, E., Szeszko, P. R., Koda, V., ... Bilder, R. M. (2001). Methods for developmental studies of fear conditioning circuitry. Biological Psychiatry, 50(3), 225-228. https://doi.org/10.1016/S0006-3223(01)01159-3

Methods for developmental studies of fear conditioning circuitry. / Pine, Daniel S.; Fyer, Abby; Grun, Joseph; Phelps, Elizabeth; Szeszko, Philip R.; Koda, Vivian; Li, Wei; Ardekani, Babak; Maguire, Eleanor A.; Burgess, Neil; Bilder, Robert M.

In: Biological Psychiatry, Vol. 50, No. 3, 01.08.2001, p. 225-228.

Research output: Contribution to journalArticle

Pine, DS, Fyer, A, Grun, J, Phelps, E, Szeszko, PR, Koda, V, Li, W, Ardekani, B, Maguire, EA, Burgess, N & Bilder, RM 2001, 'Methods for developmental studies of fear conditioning circuitry', Biological Psychiatry, vol. 50, no. 3, pp. 225-228. https://doi.org/10.1016/S0006-3223(01)01159-3
Pine, Daniel S. ; Fyer, Abby ; Grun, Joseph ; Phelps, Elizabeth ; Szeszko, Philip R. ; Koda, Vivian ; Li, Wei ; Ardekani, Babak ; Maguire, Eleanor A. ; Burgess, Neil ; Bilder, Robert M. / Methods for developmental studies of fear conditioning circuitry. In: Biological Psychiatry. 2001 ; Vol. 50, No. 3. pp. 225-228.
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