Metaplasticity at identified inhibitory synapses in Aplysia

Thomas M. Fischer, Diana E J Blazis, Naomi A. Priver, Thomas J. Carew

Research output: Contribution to journalArticle

Abstract

Synaptic plasticity is an important feature of neural networks involved in the encoding of information. In the analysis of long-term potentiation and long-term depression, several examples have emerged in which this plaStiCity is itself modulated. This higher-order form of plasticity has been referred to as 'metaplasticity', a modification of synapses reflected as a change in the ability to induce or maintain plasticity. These observations raise the question of the possible advantage of regulating the intrinsic plastic properties of a synapse. The neural circuit mediating the siphon withdrawal reflex in Aplysia provides a useful network in which to examine this question directly. Inhibitory synapses in this circuit (from L30 neurons) exhibit a variety of forms of activity-dependent short-term synaptic enhancement which contribute to dynamic gain control in the siphon withdrawal reflex. Here we report that tail shock, an extrinsic modulatory input of known behavioural relevance, induces differential metaplasticity at this synapse, attenuating its ability to exhibit short-term synaptic enhancement after pre-synaptic activation (augmentation and post-tetanic potentiation), while leaving intact its capacity for enhancement during activation. This attenuation of inhibition at the synaptic level seems to mediate comparable attenuation of inhibitory modulation at both network and behavioural levels.

Original languageEnglish (US)
Pages (from-to)860-865
Number of pages6
JournalNature
Volume389
Issue number6653
DOIs
StatePublished - 1997

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Aplysia
Synapses
Aptitude
Reflex
L 30
Neuronal Plasticity
Long-Term Potentiation
Plastics
Tail
Shock
Depression
Neurons

ASJC Scopus subject areas

  • General

Cite this

Fischer, T. M., Blazis, D. E. J., Priver, N. A., & Carew, T. J. (1997). Metaplasticity at identified inhibitory synapses in Aplysia. Nature, 389(6653), 860-865. https://doi.org/10.1038/39892

Metaplasticity at identified inhibitory synapses in Aplysia. / Fischer, Thomas M.; Blazis, Diana E J; Priver, Naomi A.; Carew, Thomas J.

In: Nature, Vol. 389, No. 6653, 1997, p. 860-865.

Research output: Contribution to journalArticle

Fischer, TM, Blazis, DEJ, Priver, NA & Carew, TJ 1997, 'Metaplasticity at identified inhibitory synapses in Aplysia', Nature, vol. 389, no. 6653, pp. 860-865. https://doi.org/10.1038/39892
Fischer, Thomas M. ; Blazis, Diana E J ; Priver, Naomi A. ; Carew, Thomas J. / Metaplasticity at identified inhibitory synapses in Aplysia. In: Nature. 1997 ; Vol. 389, No. 6653. pp. 860-865.
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