Metal ion-directed outside binding of small DNA ligand.

Toshihiro Ihara, Takashi Ikegami, Tomohiro Fujii, Yusuke Kitamura, Shinji Sueda, Makoto Takagi, Nicholas E. Geacintov, Akinori Jyo

Research output: Contribution to journalArticle


DNA binding of the ligand bearing an oxine and a pyridinium group was regulated by coexisting Cu2+ over the binding constant range of three orders of magnitude. The ligands coordinated to Cu2+ to form a dimer and then cooperatively bound outside of DNA duplex to give the well-regulated 1-D structure along the DNA backbone.

Original languageEnglish (US)
Pages (from-to)85-86
Number of pages2
JournalNucleic acids research. Supplement (2001)
Issue number3
StatePublished - 2003


ASJC Scopus subject areas

  • Medicine(all)

Cite this

Ihara, T., Ikegami, T., Fujii, T., Kitamura, Y., Sueda, S., Takagi, M., Geacintov, N. E., & Jyo, A. (2003). Metal ion-directed outside binding of small DNA ligand. Nucleic acids research. Supplement (2001), (3), 85-86.