Metabolomic Profiling to Identify Predictors of Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH)

Jianfeng Cheng, Andrew Joyce, Katherine Yates, Bradley Aouizerat, Arun J. Sanyal

Research output: Contribution to journalArticle

Abstract

Vitamin E was recently shown to improve hepatic histology in a randomized controlled trial of pioglitazone or vitamin E for nonalcoholic steatohepatitis (PIVENS). The current study utilized samples collected in the PIVENS trial to identify: (1) baseline metabolomic profiles that could identify who would respond to vitamin E treatment and (2) end of treatment metabolomic profiles reflective of histologic improvement. A comprehensive analysis of metabolomics profiles (n = 547) quantified by mass spectrometry was performed in vitamin E responders (n = 16), vitamin E non-responders (n = 15), and placebo responders (n = 15). At baseline, phenyl-propionic acid (Odds ratio: 29.4, p

Original languageEnglish (US)
Article numbere44106
JournalPLoS One
Volume7
Issue number9
DOIs
StatePublished - Sep 19 2012

Fingerprint

Metabolomics
metabolomics
Fatty Liver
Vitamin E
vitamin E
pioglitazone
Histology
propionic acid
odds ratio
histology
placebos
Mass spectrometry
Mass Spectrometry
Randomized Controlled Trials
Odds Ratio
Placebos
mass spectrometry
liver
Liver
Therapeutics

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Metabolomic Profiling to Identify Predictors of Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH). / Cheng, Jianfeng; Joyce, Andrew; Yates, Katherine; Aouizerat, Bradley; Sanyal, Arun J.

In: PLoS One, Vol. 7, No. 9, e44106, 19.09.2012.

Research output: Contribution to journalArticle

Cheng, Jianfeng ; Joyce, Andrew ; Yates, Katherine ; Aouizerat, Bradley ; Sanyal, Arun J. / Metabolomic Profiling to Identify Predictors of Response to Vitamin E for Non-Alcoholic Steatohepatitis (NASH). In: PLoS One. 2012 ; Vol. 7, No. 9.
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