Metabolic modulation of potassium channels.

Dirk Trauner, Richard H. Kramer

Research output: Contribution to journalReview article

Abstract

Recent investigations have shown that a range of small molecules that reflect the metabolic state of a cell regulate the activity of potassium channels. For instance, hydrogen peroxide has been shown to activate adenosine 5'-triphosphate-sensitive potassium channels (K(ATP) channels), whereas heme closes certain calcium-activated potassium channels. Although the exact function of the beta subunit associated with voltage-gated potassium channels is still unclear, its crystal structure suggests that membrane excitability is directly coupled to metabolism.

Original languageEnglish (US)
JournalScience's STKE : signal transduction knowledge environment
Volume2004
Issue number233
StatePublished - 2004

Fingerprint

Voltage-Gated Potassium Channels
Calcium-Activated Potassium Channels
KATP Channels
Potassium Channels
Heme
Hydrogen Peroxide
Adenosine Triphosphate
Modulation
Membranes
Metabolism
Adenosine
Crystal structure
Molecules
triphosphoric acid

Cite this

Metabolic modulation of potassium channels. / Trauner, Dirk; Kramer, Richard H.

In: Science's STKE : signal transduction knowledge environment, Vol. 2004, No. 233, 2004.

Research output: Contribution to journalReview article

Trauner, Dirk ; Kramer, Richard H. / Metabolic modulation of potassium channels. In: Science's STKE : signal transduction knowledge environment. 2004 ; Vol. 2004, No. 233.
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