Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdala

Glenn E. Schafe, Elizabeth P. Bauer, Svetlana Rosis, Claudia R. Farb, Sarina M. Rodrigues, Joseph Ledoux

Research output: Contribution to journalArticle

Abstract

Nitric oxide (NO) has been widely implicated in synaptic plasticity and memory formation. In studies of long-term potentiation (LTP), NO is thought to serve as a 'retrograde messenger' that contributes to presynaptic aspects of LTP expression. In this study, we examined the role of NO signaling in Pavlovian fear conditioning. We first show that neuronal nitric oxide synthase is localized in the lateral nucleus of the amygdala (LA), a critical site of plasticity in fear conditioning. We next show that NO signaling is required for LTP at thalamic inputs to the LA and for the long-term consolidation of auditory fear conditioning. Collectively, the findings suggest that NO signaling is an important component of memory formation of auditory fear conditioning, possibly as a retrograde signal that participates in presynaptic aspects of plasticity in the LA.

Original languageEnglish (US)
Pages (from-to)201-211
Number of pages11
JournalEuropean Journal of Neuroscience
Volume22
Issue number1
DOIs
StatePublished - Jul 2005

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Amygdala
Fear
Nitric Oxide
Long-Term Potentiation
Nitric Oxide Synthase Type I
Neuronal Plasticity
Memory Consolidation
Conditioning (Psychology)

Keywords

  • Amygdala
  • Fear conditioning
  • Nitric oxide
  • Plasticity
  • Rat

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdala. / Schafe, Glenn E.; Bauer, Elizabeth P.; Rosis, Svetlana; Farb, Claudia R.; Rodrigues, Sarina M.; Ledoux, Joseph.

In: European Journal of Neuroscience, Vol. 22, No. 1, 07.2005, p. 201-211.

Research output: Contribution to journalArticle

Schafe, Glenn E. ; Bauer, Elizabeth P. ; Rosis, Svetlana ; Farb, Claudia R. ; Rodrigues, Sarina M. ; Ledoux, Joseph. / Memory consolidation of Pavlovian fear conditioning requires nitric oxide signaling in the lateral amygdala. In: European Journal of Neuroscience. 2005 ; Vol. 22, No. 1. pp. 201-211.
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