Meiosis

A PRDM9 Guide to the Hotspots of Recombination

Andreas Hochwagen, Gabriel A B. Marais

Research output: Contribution to journalArticle

Abstract

During meiosis, homologous recombination occurs preferentially at defined hotspots. In mammals, the fast-evolving DNA-binding domain of PRDM9 has now been identified as a major hotspot determinant that may explain the rapid rates of hotspot redistribution during evolution.

Original languageEnglish (US)
JournalCurrent Biology
Volume20
Issue number6
DOIs
StatePublished - Mar 23 2010

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Mammals
DNA-binding domains
Homologous Recombination
homologous recombination
Meiosis
meiosis
Genetic Recombination
mammals
DNA

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Meiosis : A PRDM9 Guide to the Hotspots of Recombination. / Hochwagen, Andreas; Marais, Gabriel A B.

In: Current Biology, Vol. 20, No. 6, 23.03.2010.

Research output: Contribution to journalArticle

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