Mechanistic insights from reversible splicing catalysis

Duncan Smith, Maria M. Konarska

Research output: Contribution to journalArticle

Abstract

Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.

Original languageEnglish (US)
Pages (from-to)1975-1978
Number of pages4
JournalRNA
Volume14
Issue number10
DOIs
StatePublished - Oct 2008

Fingerprint

Spliceosomes
Catalysis

Keywords

  • Active site
  • ATPases
  • Conformational toggling
  • Reversible splicing
  • Spliced exon reopening

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Mechanistic insights from reversible splicing catalysis. / Smith, Duncan; Konarska, Maria M.

In: RNA, Vol. 14, No. 10, 10.2008, p. 1975-1978.

Research output: Contribution to journalArticle

Smith, Duncan ; Konarska, Maria M. / Mechanistic insights from reversible splicing catalysis. In: RNA. 2008 ; Vol. 14, No. 10. pp. 1975-1978.
@article{e437d33789a4495abc894156ebd8a2da,
title = "Mechanistic insights from reversible splicing catalysis",
abstract = "Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.",
keywords = "Active site, ATPases, Conformational toggling, Reversible splicing, Spliced exon reopening",
author = "Duncan Smith and Konarska, {Maria M.}",
year = "2008",
month = "10",
doi = "10.1261/rna.1289808",
language = "English (US)",
volume = "14",
pages = "1975--1978",
journal = "RNA",
issn = "1355-8382",
publisher = "Cold Spring Harbor Laboratory Press",
number = "10",

}

TY - JOUR

T1 - Mechanistic insights from reversible splicing catalysis

AU - Smith, Duncan

AU - Konarska, Maria M.

PY - 2008/10

Y1 - 2008/10

N2 - Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.

AB - Recent work demonstrating the ability of spliceosomes purified after the second catalytic step of splicing to efficiently reverse both steps of the reaction provides answers to several unresolved questions regarding the splicing reaction, and raises many more.

KW - Active site

KW - ATPases

KW - Conformational toggling

KW - Reversible splicing

KW - Spliced exon reopening

UR - http://www.scopus.com/inward/record.url?scp=52949135935&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52949135935&partnerID=8YFLogxK

U2 - 10.1261/rna.1289808

DO - 10.1261/rna.1289808

M3 - Article

VL - 14

SP - 1975

EP - 1978

JO - RNA

JF - RNA

SN - 1355-8382

IS - 10

ER -