Mechanisms of memory enhancement

Sarah A. Stern, Cristina Alberini

Research output: Contribution to journalArticle

Abstract

The ongoing quest for memory enhancement is one that grows necessary as the global population increasingly ages. The extraordinary progress that has been made in the past few decades elucidating the underlying mechanisms of how long-term memories are formed has provided insight into how memories might also be enhanced. Capitalizing on this knowledge, it has been postulated that targeting many of the same mechanisms, including CREB activation, AMPA/NMDA receptor trafficking, neuromodulation (e.g., via dopamine, adrenaline, cortisol, or acetylcholine) and metabolic processes (e.g., via glucose and insulin) may all lead to the enhancement of memory. These and other mechanisms and/or approaches have been tested via genetic or pharmacological methods in animal models, and several have been investigated in humans as well. In addition, a number of behavioral methods, including exercise and reconsolidation, may also serve to strengthen and enhance memories. By utilizing this information and continuing to investigate these promising avenues, memory enhancement may indeed be achieved in the future.

Original languageEnglish (US)
Pages (from-to)37-53
Number of pages17
JournalWiley Interdisciplinary Reviews: Systems Biology and Medicine
Volume5
Issue number1
DOIs
StatePublished - Jan 2013

Fingerprint

Data storage equipment
AMPA Receptors
Long-Term Memory
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
N-Methyl-D-Aspartate Receptors
Epinephrine
Acetylcholine
Hydrocortisone
Dopamine
Animal Models
Pharmacology
Insulin
Animals
Glucose
Chemical activation
Population

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Medicine (miscellaneous)

Cite this

Mechanisms of memory enhancement. / Stern, Sarah A.; Alberini, Cristina.

In: Wiley Interdisciplinary Reviews: Systems Biology and Medicine, Vol. 5, No. 1, 01.2013, p. 37-53.

Research output: Contribution to journalArticle

@article{aa3e60d50e494db38a7c277465aa3a6d,
title = "Mechanisms of memory enhancement",
abstract = "The ongoing quest for memory enhancement is one that grows necessary as the global population increasingly ages. The extraordinary progress that has been made in the past few decades elucidating the underlying mechanisms of how long-term memories are formed has provided insight into how memories might also be enhanced. Capitalizing on this knowledge, it has been postulated that targeting many of the same mechanisms, including CREB activation, AMPA/NMDA receptor trafficking, neuromodulation (e.g., via dopamine, adrenaline, cortisol, or acetylcholine) and metabolic processes (e.g., via glucose and insulin) may all lead to the enhancement of memory. These and other mechanisms and/or approaches have been tested via genetic or pharmacological methods in animal models, and several have been investigated in humans as well. In addition, a number of behavioral methods, including exercise and reconsolidation, may also serve to strengthen and enhance memories. By utilizing this information and continuing to investigate these promising avenues, memory enhancement may indeed be achieved in the future.",
author = "Stern, {Sarah A.} and Cristina Alberini",
year = "2013",
month = "1",
doi = "10.1002/wsbm.1196",
language = "English (US)",
volume = "5",
pages = "37--53",
journal = "Wiley Interdisciplinary Reviews: Systems Biology and Medicine",
issn = "1939-5094",
publisher = "John Wiley and Sons Inc.",
number = "1",

}

TY - JOUR

T1 - Mechanisms of memory enhancement

AU - Stern, Sarah A.

AU - Alberini, Cristina

PY - 2013/1

Y1 - 2013/1

N2 - The ongoing quest for memory enhancement is one that grows necessary as the global population increasingly ages. The extraordinary progress that has been made in the past few decades elucidating the underlying mechanisms of how long-term memories are formed has provided insight into how memories might also be enhanced. Capitalizing on this knowledge, it has been postulated that targeting many of the same mechanisms, including CREB activation, AMPA/NMDA receptor trafficking, neuromodulation (e.g., via dopamine, adrenaline, cortisol, or acetylcholine) and metabolic processes (e.g., via glucose and insulin) may all lead to the enhancement of memory. These and other mechanisms and/or approaches have been tested via genetic or pharmacological methods in animal models, and several have been investigated in humans as well. In addition, a number of behavioral methods, including exercise and reconsolidation, may also serve to strengthen and enhance memories. By utilizing this information and continuing to investigate these promising avenues, memory enhancement may indeed be achieved in the future.

AB - The ongoing quest for memory enhancement is one that grows necessary as the global population increasingly ages. The extraordinary progress that has been made in the past few decades elucidating the underlying mechanisms of how long-term memories are formed has provided insight into how memories might also be enhanced. Capitalizing on this knowledge, it has been postulated that targeting many of the same mechanisms, including CREB activation, AMPA/NMDA receptor trafficking, neuromodulation (e.g., via dopamine, adrenaline, cortisol, or acetylcholine) and metabolic processes (e.g., via glucose and insulin) may all lead to the enhancement of memory. These and other mechanisms and/or approaches have been tested via genetic or pharmacological methods in animal models, and several have been investigated in humans as well. In addition, a number of behavioral methods, including exercise and reconsolidation, may also serve to strengthen and enhance memories. By utilizing this information and continuing to investigate these promising avenues, memory enhancement may indeed be achieved in the future.

UR - http://www.scopus.com/inward/record.url?scp=84871396748&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84871396748&partnerID=8YFLogxK

U2 - 10.1002/wsbm.1196

DO - 10.1002/wsbm.1196

M3 - Article

VL - 5

SP - 37

EP - 53

JO - Wiley Interdisciplinary Reviews: Systems Biology and Medicine

JF - Wiley Interdisciplinary Reviews: Systems Biology and Medicine

SN - 1939-5094

IS - 1

ER -