MECHANISMS OF INTERACTION OF POLYCYCLIC AROMATIC DIOL EPOXIDES WITH DNA AND STRUCTURES OF THE ADDUCTS.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Spectroscopic studies on complexes derived from the binding of benzo(a)pyrene-7,8-diol-9,10-epoxide (BaPDE) to DNA indicate that the conformations of the adducts can be broadly classified into two types: site I which displays most of the properties of intercalative adducts, and site II which is characterized by an orientation of the planar aromatic residues tilted closer to the axis of the helix. Both the syn and the anti diastereomers of BaPDE-form unstable type I physical intercalation complexes and undergo specific and general acid catalysis to form tetraols ( greater than 90%) and covalent adducts ( less than 10%). (Edtied author abstract)

Original languageEnglish (US)
Title of host publicationACS Symposium Series
EditorsRonald G. Harvey
PublisherACS
Pages107-124
Number of pages18
ISBN (Print)0841209243
StatePublished - 1985

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7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Epoxy Compounds
DNA
Intercalation
Catalysis
Conformations
Acids

ASJC Scopus subject areas

  • Chemistry(all)

Cite this

MECHANISMS OF INTERACTION OF POLYCYCLIC AROMATIC DIOL EPOXIDES WITH DNA AND STRUCTURES OF THE ADDUCTS. / Geacintov, Nicholas.

ACS Symposium Series. ed. / Ronald G. Harvey. ACS, 1985. p. 107-124.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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