Mechanisms of HTLV-1 transformation.

Kylene Kehn, Reem Berro, Cynthia de la Fuente, Katharine Strouss, Elodie Ghedin, Shabnam Dadgar, Maria Elena Bottazzi, Anne Pumfery, Fatah Kashanchi

Research output: Contribution to journalArticle

Abstract

HTLV-1 is the etiological agent of the fatal disease adult T-cell leukemia. The virus encodes many proteins including several accessory proteins, p12I, p13II, p27I, and p30II, whose roles have recently begun to be elucidated. These accessory proteins are important in T-cell activation, transcriptional regulation, viral persistence, and virus assembly. The viral oncogene Tax is thought to be largely responsible for tumorigenesis, although the precise mechanisms underlying transformation are not completely understood. Tax has a profound impact on transcription, cell growth regulation, genomic stability and apoptosis. This review will provide possible contributions of the accessory proteins to transformation as well as highlight the alterations of the above-mentioned cellular events by Tax. Animal models of both Tax and the accessory proteins are also included based on the essential information on the transformation process in vivo that they provide.

Original languageEnglish (US)
Pages (from-to)2347-2372
Number of pages26
JournalFrontiers in bioscience : a journal and virtual library
Volume9
StatePublished - 2004

Fingerprint

Human T-lymphotropic virus 1
Accessories
Taxation
Virus Assembly
T-cells
Proteins
Viruses
tax Gene Products
Adult T Cell Leukemia Lymphoma
Genomic Instability
Oncogenes
Transcriptional Activation
Cell growth
Transcription
Carcinogenesis
Animal Models
Apoptosis
T-Lymphocytes
Animals
Chemical activation

Cite this

Kehn, K., Berro, R., de la Fuente, C., Strouss, K., Ghedin, E., Dadgar, S., ... Kashanchi, F. (2004). Mechanisms of HTLV-1 transformation. Frontiers in bioscience : a journal and virtual library, 9, 2347-2372.

Mechanisms of HTLV-1 transformation. / Kehn, Kylene; Berro, Reem; de la Fuente, Cynthia; Strouss, Katharine; Ghedin, Elodie; Dadgar, Shabnam; Bottazzi, Maria Elena; Pumfery, Anne; Kashanchi, Fatah.

In: Frontiers in bioscience : a journal and virtual library, Vol. 9, 2004, p. 2347-2372.

Research output: Contribution to journalArticle

Kehn, K, Berro, R, de la Fuente, C, Strouss, K, Ghedin, E, Dadgar, S, Bottazzi, ME, Pumfery, A & Kashanchi, F 2004, 'Mechanisms of HTLV-1 transformation.', Frontiers in bioscience : a journal and virtual library, vol. 9, pp. 2347-2372.
Kehn K, Berro R, de la Fuente C, Strouss K, Ghedin E, Dadgar S et al. Mechanisms of HTLV-1 transformation. Frontiers in bioscience : a journal and virtual library. 2004;9:2347-2372.
Kehn, Kylene ; Berro, Reem ; de la Fuente, Cynthia ; Strouss, Katharine ; Ghedin, Elodie ; Dadgar, Shabnam ; Bottazzi, Maria Elena ; Pumfery, Anne ; Kashanchi, Fatah. / Mechanisms of HTLV-1 transformation. In: Frontiers in bioscience : a journal and virtual library. 2004 ; Vol. 9. pp. 2347-2372.
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