MCC and PSC, the putative protein import channels of mitochondria

Kathleen W. Kinnally, Concepción Muro, María Luisa Campo

Research output: Contribution to journalArticle

Abstract

All but a small fraction of the hundreds of proteins in a mitochondrion are synthesized in the cytoplasm and imported into the organelle. Water- filled channels are integral to the process of translocating proteins since channels can provide an aqueous pathway through the hydrophobic environment of the membrane. The MCC (multiple conductance channel) and PSC (peptide- sensitive channel) are two high-conductance channels previously identified in electrophysiological studies of mitochondrial membranes. MCC and PSC are the putative pores of the import complexes of the inner and outer membranes, respectively. The genetic, biochemical, and biophysical evidence regarding these assignments are summarized herein. These findings support the identification of MCC and PSC as the protein import channels of mitochondria.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalJournal of Bioenergetics and Biomembranes
Volume32
Issue number1
DOIs
StatePublished - 2000

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Mitochondria
Aquaporins
Proteins
Membranes
Mitochondrial Membranes
Organelles
Molecular Biology
Cytoplasm
peptide sensitive channel

Keywords

  • Import pore
  • MCC
  • Mitochondria
  • Protein import
  • Protein-translocating channels
  • PSC

ASJC Scopus subject areas

  • Physiology
  • Cell Biology

Cite this

MCC and PSC, the putative protein import channels of mitochondria. / Kinnally, Kathleen W.; Muro, Concepción; Campo, María Luisa.

In: Journal of Bioenergetics and Biomembranes, Vol. 32, No. 1, 2000, p. 47-54.

Research output: Contribution to journalArticle

Kinnally, Kathleen W. ; Muro, Concepción ; Campo, María Luisa. / MCC and PSC, the putative protein import channels of mitochondria. In: Journal of Bioenergetics and Biomembranes. 2000 ; Vol. 32, No. 1. pp. 47-54.
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