Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat

N. D. Macon, A. Schwartz, K. James, X. Tong, J. Charvet, John Ricci

Research output: Contribution to conferencePaper

Abstract

Poly(desaminotyrosyl-tyrosine ethyl ester carbonate), or PDTEc, is a candidate bioresorbable polymer for use in small bone fracture fixation and is shown to generate a good hard tissue response in vivo. The general effect of the in vivo environment on bone pin prototypes made of either 44.2-kDa or 71.8-kDa weight-average molecular weight (Mw) PDTEc is determined through mechanical testing and gel permeation chromatography (GPC) analysis of retrieved specimens. Results indicate that the lower-molecular-weight material is useful in biodistribution studies of PDTEc degradation products. The higher-molecular-weight material is useful in further orthopedic device prototype development.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

Fingerprint

Rats
Carbonates
Materials properties
Esters
Molecular weight
Bone
Fracture fixation
Mechanical testing
Orthopedics
Gel permeation chromatography
Polymers
Tissue
Degradation
poly(desaminotyrosyl-tyrosine-ethyl ester carbonate)

ASJC Scopus subject areas

  • Materials Science(all)

Cite this

Macon, N. D., Schwartz, A., James, K., Tong, X., Charvet, J., & Ricci, J. (1996). Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .

Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat. / Macon, N. D.; Schwartz, A.; James, K.; Tong, X.; Charvet, J.; Ricci, John.

1996. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .

Research output: Contribution to conferencePaper

Macon, ND, Schwartz, A, James, K, Tong, X, Charvet, J & Ricci, J 1996, 'Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat' Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, 5/29/96 - 6/2/96, .
Macon ND, Schwartz A, James K, Tong X, Charvet J, Ricci J. Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat. 1996. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .
Macon, N. D. ; Schwartz, A. ; James, K. ; Tong, X. ; Charvet, J. ; Ricci, John. / Material properties of poly(desaminotyrosyl-tyrosine ethyl ester carbonate) at two molecular weights after subcutaneous implantation in the rat. Paper presented at Proceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2), Toronto, Can, .1 p.
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AU - Schwartz, A.

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AU - Charvet, J.

AU - Ricci, John

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